P2RX7

From Wikipedia, the free encyclopedia

Purinergic receptor P2X, ligand-gated ion channel, 7

Identifiers

P2RX7; MGC20089; P2X7

External IDs

OMIM: 602566 MGI: 1339957 HomoloGene: 1925

Gene ontology
Molecular Function:	• receptor activity • ATP-gated cation channel activity • ion channel activity • ATP binding
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• ion transport • cation transport • signal transduction • positive regulation of bone mineralization • negative regulation of bone resorption

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002562 (mRNA)
NP_002553 (protein)

NM_001038839 (mRNA)
NP_001033928 (protein)

Location

Chr 12: 120.06 - 120.11 Mb

Chr 5: 122.9 - 122.95 Mb

Pubmed search

[1]

[2]

Purinergic receptor P2X, ligand-gated ion channel, 7, also known as P2RX7, is a human gene.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

[edit] References

^ Entrez Gene: P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7.

[edit] Further reading

Gartland A, Buckley KA, Hipskind RA, Bowler WB, Gallagher JA. (2003). "P2 receptors in bone--modulation of osteoclast formation and activity via P2X7 activation.". Crit Rev Eukaryot Gene Expr. 13 (2-4): 237-42. PMID 14696970.
Gartland A, Buckley KA, Bowler WB, Gallagher JA. (2003). "Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro.". Calcif Tissue Int. 72 (4): 361-9. PMID 12874700.
Bowler WB, Buckley KA, Gartland A, Hipskind RA, Bilbe G, Gallagher JA.. "Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling.". Bone 28 (5): 507-12. PMID 11344050.
Gartland A, Hipskind RA, Gallagher JA, Bowler WB. (2001). "Expression of a P2X7 receptor by a subpopulation of human osteoblasts.". J Bone Miner Res . 16 (5): 846-56. PMID 11341329.
Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB, Gallagher JA. (2003). "Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice.". Crit Rev Eukaryot Gene Expr. 13 (2-4): 243-53. PMID 14696971.
North RA (2002). "Molecular physiology of P2X receptors.". Physiol. Rev. 82 (4): 1013-67. doi:10.1152/physrev.00015.2002. PMID 12270951.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Rassendren F, Buell GN, Virginio C, et al. (1997). "The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA.". J. Biol. Chem. 272 (9): 5482-6. PMID 9038151.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Buell GN, Talabot F, Gos A, et al. (1999). "Gene structure and chromosomal localization of the human P2X7 receptor.". Recept. Channels 5 (6): 347-54. PMID 9826911.
Gu BJ, Zhang W, Worthington RA, et al. (2001). "A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor.". J. Biol. Chem. 276 (14): 11135-42. doi:10.1074/jbc.M010353200. PMID 11150303.
Kim M, Jiang LH, Wilson HL, et al. (2002). "Proteomic and functional evidence for a P2X7 receptor signalling complex.". EMBO J. 20 (22): 6347-58. doi:10.1093/emboj/20.22.6347. PMID 11707406.
Worthington RA, Smart ML, Gu BJ, et al. (2002). "Point mutations confer loss of ATP-induced human P2X(7) receptor function.". FEBS Lett. 512 (1-3): 43-6. PMID 11852049.
Wiley JS, Dao-Ung LP, Gu BJ, et al. (2002). "A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study.". Lancet 359 (9312): 1114-9. PMID 11943260.
Wilson HL, Wilson SA, Surprenant A, North RA (2002). "Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.". J. Biol. Chem. 277 (37): 34017-23. doi:10.1074/jbc.M205120200. PMID 12107182.
Atkinson L, Milligan CJ, Buckley NJ, Deuchars J (2002). "An ATP-gated ion channel at the cell nucleus.". Nature 420 (6911): 42. doi:10.1038/420042a. PMID 12422208.
Budagian V, Bulanova E, Brovko L, et al. (2003). "Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B.". J. Biol. Chem. 278 (3): 1549-60. doi:10.1074/jbc.M206383200. PMID 12424250.
Sluyter R, Wiley JS (2003). "Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors.". Int. Immunol. 14 (12): 1415-21. PMID 12456589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wiley JS, Dao-Ung LP, Li C, et al. (2003). "An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor.". J. Biol. Chem. 278 (19): 17108-13. doi:10.1074/jbc.M212759200. PMID 12586825.
Barden JA, Sluyter R, Gu BJ, Wiley JS (2003). "Specific detection of non-functional human P2X(7) receptors in HEK293 cells and B-lymphocytes.". FEBS Lett. 538 (1-3): 159-62. PMID 12633871.
Verhoef PA, Estacion M, Schilling W, Dubyak GR (2003). "P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.". J. Immunol. 170 (11): 5728-38. PMID 12759456.
Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.". J. Invest. Dermatol. 120 (6): 1007-15. PMID 12787128.
Denlinger LC, Sommer JA, Parker K, et al. (2003). "Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function.". J. Immunol. 171 (3): 1304-11. PMID 12874219.

[edit] External links

MeSH P2RX7+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Ion channel, receptor: ligand-gated ion channels

Cys-loop receptors	5-HT/serotonin: 5-HT₃ (A) GABA: GABA A (α₁, α₂, α₃, α₄, α₅, α₆, β₁, β₂, β₃, γ₂, γ₃, δ, ε, π), GABA C (ρ₁, ρ₂) Glycine: α₁, α₂, β Nicotinic acetylcholine: α1, α2, α3, α4, α5, α7, α9, β1, β2, β3, β4, δ, ε, combinations ((α4)₂(β2)₃, (α7)₅, Ganglion type, Muscle type)

Ionotropic glutamates	AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D)

ATP-gated channels	Purinergic receptors: P2X (1, 2, 3, 4, 5, 6, 7)