P2RX6

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Purinergic receptor P2X-like 1, orphan receptor
Identifiers
Symbol(s) P2RXL1; MGC129625; P2RX6; P2X6; P2XM
External IDs OMIM: 608077 MGI: 1337113 HomoloGene: 3975
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9127 18440
Ensembl ENSG00000099957 ENSMUSG00000022758
Uniprot O15547 Q3UUD0
Refseq NM_005446 (mRNA)
NP_005437 (protein)		 NM_011028 (mRNA)
NP_035158 (protein)
Location Chr 22: 19.7 - 19.71 Mb Chr 16: 17.48 - 17.49 Mb
Pubmed search [1] [2]

Purinergic receptor P2X-like 1, orphan receptor, also known as P2RXL1, is a human gene.[1]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor.

[edit] Further reading

  • Khakh BS, Burnstock G, Kennedy C, et al. (2001). "International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.". Pharmacol. Rev. 53 (1): 107-18. PMID 11171941. 
  • Soto F, Garcia-Guzman M, Karschin C, Stühmer W (1996). "Cloning and tissue distribution of a novel P2X receptor from rat brain.". Biochem. Biophys. Res. Commun. 223 (2): 456-60. doi:10.1006/bbrc.1996.0915. PMID 8670303. 
  • Urano T, Nishimori H, Han H, et al. (1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53.". Cancer Res. 57 (15): 3281-7. PMID 9242461. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208. 
  • Glass R, Loesch A, Bodin P, Burnstock G (2002). "P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells.". Cell. Mol. Life Sci. 59 (5): 870-81. PMID 12088286. 
  • Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets.". Proteomics 2 (6): 642-8. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Barrera NP, Ormond SJ, Henderson RM, et al. (2005). "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize.". J. Biol. Chem. 280 (11): 10759-65. doi:10.1074/jbc.M412265200. PMID 15657042. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 

[edit] External links

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Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors
Ionotropic glutamates
AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D)
ATP-gated channels