P-type calcium channel
From Wikipedia, the free encyclopedia
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calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
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| Identifiers | |
| Symbol | CACNA1A |
| Alt. Symbols | CACNL1A4, SCA6, MHP1, MHP |
| Entrez | 773 |
| HUGO | 1388 |
| OMIM | 601011 |
| RefSeq | NM_000068 |
| UniProt | O00555 |
| Other data | |
| Locus | Chr. 19 p13 |
The p-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
P-type ('P' for cerebellar Purkinje cells) calcium channels play a similar role to the N-type calcium channel in neurotransmitter release at the presynaptic terminal, and in neuronal integration in many neuronal types.
They are also found in Purkinje fibers in the electrical conduction system of the heart. Their properties are less well understood.
P channels were discovered in cerebellar Purkinje cells by Llinas and Sugimori[1] and named P channels by Llinas et al.[2]
[edit] References
- ^ Llinás R, Sugimori M (1980). "Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices". J. Physiol. (Lond.) 305: 171–95. PMID 7441552.
- ^ Llinás R, Sugimori M, Lin JW, Cherksey B (1989). "Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison". Proc. Natl. Acad. Sci. U.S.A. 86 (5): 1689–93. PMID 2537980.
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