P-selectin
From Wikipedia, the free encyclopedia
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Selectin P (granule membrane protein 140kDa, antigen CD62)
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| PDB rendering based on pdb 1gsr. | ||||||||||||||
| Available structures: 1fsb, 1g1q, 1g1r, 1g1s | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | SELP; CD62; CD62P; FLJ45155; GMP140; GRMP; PADGEM; PSEL | |||||||||||||
| External IDs | OMIM: 173610 MGI: 98280 HomoloGene: 2260 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 6403 | 20344 | ||||||||||||
| Ensembl | ENSG00000174175 | ENSMUSG00000026580 | ||||||||||||
| Uniprot | P16109 | Q32MF1 | ||||||||||||
| Refseq | NM_003005 (mRNA) NP_002996 (protein) |
XM_982736 (mRNA) XP_987830 (protein) |
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| Location | Chr 1: 167.82 - 167.87 Mb | Chr 1: 165.96 - 165.99 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
P-selectin is a cell adhesion molecule (CAM) found in granules in endothelial cells (cells lining blood vessels) and activated platelets. Other names for P-selectin include CD62P, Granule Membrane Protein 140 (GMP-140), and Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM). It was first shown to be found in endothelial cells in 1989.
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[edit] Function
P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface.
Thrombin is one trigger which can stimulate endothelial-cell release of P-selectin and recent studies suggest an additional Ca2+-independent pathway involved in release of P-selectin. [1]
Ligands for P-selectin on eosinophils and neutrophils are similar sialylated, protease-sensitive, endo-beta-galactosidase-resistant structures, clearly different than those reported for E-selectin, and suggest disparate roles for P-selectin and E-selectin during recruitment during inflammatory responses. [2]
[edit] Location
Endothelial cells: stored in the membrane of Weibel-Palade bodies.
Platelets: stored in alpha-granules.
[edit] See also
[edit] Footnotes
- ^ Cleator, JH (Apr 2006). "Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP.". blood 107 (7): 2736–44. doi:. 16332977.
- ^ Wein, M (1995). "Comparison of human eosinophil and neutrophil ligands for P-selectin: ligands for P-selectin differ from those for E-selectin.". Am J Respir Cell Mol Biol. 12 (3): 315–9.
[edit] Further reading
- Ryan US, Worthington RE (1992). "Cell-cell contact mechanisms.". Curr. Opin. Immunol. 4 (1): 33–7. PMID 1375831.
- Bajorath J, Stenkamp R, Aruffo A (1994). "Knowledge-based model building of proteins: concepts and examples.". Protein Sci. 2 (11): 1798–810. PMID 7505680.
- Varki NM, Varki A (2002). "Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans.". Semin. Thromb. Hemost. 28 (1): 53–66. doi:. PMID 11885026.
- Furie B, Furie BC (2004). "Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation.". Trends in molecular medicine 10 (4): 171–8. doi:. PMID 15059608.
- Cambien B, Wagner DD (2004). "A new role in hemostasis for the adhesion receptor P-selectin.". Trends in molecular medicine 10 (4): 179–86. doi:. PMID 15059609.
- Chen M, Geng JG (2006). "P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis.". Arch. Immunol. Ther. Exp. (Warsz.) 54 (2): 75–84. doi:. PMID 16648968.
[edit] External links
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