Oxetacaine

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Oxetacaine
Systematic (IUPAC) name
2,2'-(2-hydroxyethylimino)bis [N-(1,1-dimethyl-2- phenylethyl)-N-methylacetamide]
Identifiers
CAS number 126-27-2
ATC code C05AD06
PubChem 4621
Chemical data
Formula C28H41N3O3 
Mol. mass 467.643 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 1 hour
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes Oral, topical

Oxetacaine (INN, also known as oxethazaine) is a potent local anesthetic. It is administered orally (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. It is also used topically in the management of hemorrhoid pain. Oral oxetacaine preparations are available in several countries, including India, South Africa, Japan and Brazil, but not the United States; oxetacaine was withdrawn from the UK market in 2002.

Unlike most local anesthetics, oxetacaine is active even in strongly acidic conditions.[1]

[edit] References

  1. ^ Seifter J, Glassman JM, Hudyma GM (1962). "Oxethazaine and related congeners: a series of highly potent local anesthetics". Proc Soc Exp Biol Med 109: 664–8. PMID 13910333. 

[edit] External links

Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Anesthetics: Local anesthetics (N01B)
Esters of aminobenzoic acid
Amylocaine, Benzocaine, Butacaine, Chloroprocaine, Dimethocaine, Meprylcaine, Metabutozycaine, Orthocaine, Propoxycaine, Procaine, Proparacaine, Risocaine, Tetracaine
Amides
Esters of benzoic acid
Other
v • d • e
Vasoprotectives (C05)
Antihemorrhoidals for topical use
Antivaricose therapy
heparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate)

sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol)

other (Calcium dobesilate)
Capillary stabilising agents