Oxaprozin

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Oxaprozin
Systematic (IUPAC) name
3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
Identifiers
CAS number	21256-18-8
ATC code	M01AE12
PubChem	4614
DrugBank	APRD00030
Chemical data
Formula	C18H15NO3
Mol. mass	293.317 g/mol
Pharmacokinetic data
Bioavailability	95%
Protein binding	99%
Metabolism	Liver—65% oxidation and 35% glucuronic acid conjugation. 5% are active phenolic metabolites.
Half life	54.9 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C
Legal status
Routes	Oral

Oxaprozin, also known as Oxaprozinum, (sold under the names: Daypro or Duraprox) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. It is available in 600 mg tablets. Normal adult dosage is 1200 mg daily, not to exceed 1800 mg per day. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.

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