Outer membrane efflux proteins
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| Outer membrane efflux protein | ||
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| Identifiers | ||
| Symbol | OEP | |
| Pfam | PF02321 | |
| InterPro | IPR003423 | |
| SCOP | 1ek9 | |
| TCDB | 2.A.6 | |
| OPM family | 34 | |
| OPM protein | 1yc9 | |
| Available PDB structures: | ||
Outer membrane efflux protein family form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.
Examples include the Escherichia coli TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.
[edit] Subfamilies
- Type I secretion outer membrane protein, TolC IPR010130
- RND efflux system, outer membrane lipoprotein, NodT IPR010131
[edit] References
- Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps. Johnson JM, Church GM; J Mol Biol 1999;287:695-715. PubMed
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