Outer membrane efflux proteins

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Outer membrane efflux protein
Identifiers
Symbol OEP
Pfam PF02321
InterPro IPR003423
SCOP 1ek9
TCDB 2.A.6
OPM family 34
OPM protein 1yc9
Available PDB structures:

1ek9B:25-209 1tqqA:25-209 1yc9A:77-267 1wp1A:66-256

Outer membrane efflux protein family form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.

Examples include the Escherichia coli TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.

[edit] Subfamilies

  • Type I secretion outer membrane protein, TolC IPR010130
  • RND efflux system, outer membrane lipoprotein, NodT IPR010131

[edit] References

  • Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps. Johnson JM, Church GM; J Mol Biol 1999;287:695-715. PubMed