OTUB2

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OTU domain, ubiquitin aldehyde binding 2
PDB rendering based on 1tff.
Available structures: 1tff
Identifiers
Symbol(s) OTUB2; C14orf137; FLJ21916; MGC3102; OTB2; OTU2
External IDs OMIM: 608338 MGI: 1915399 HomoloGene: 57056
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 78990 68149
Ensembl ENSG00000089723 ENSMUSG00000021203
Uniprot Q96DC9 Q9CQX0
Refseq NM_023112 (mRNA)
NP_075601 (protein)		 NM_026580 (mRNA)
NP_080856 (protein)
Location Chr 14: 93.56 - 93.59 Mb Chr 12: 103.79 - 103.81 Mb
Pubmed search [1] [2]

OTU domain, ubiquitin aldehyde binding 2, also known as OTUB2, is a human gene.[1]

Otubains are deubiquitylating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2.

[edit] Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Nanao MH, Tcherniuk SO, Chroboczek J, et al. (2005). "Crystal structure of human otubain 2.". EMBO Rep. 5 (8): 783-8. doi:10.1038/sj.embor.7400201. PMID 15258613. 
  • Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.". Mamm. Genome 15 (3): 162-78. doi:10.1007/s00335-003-2311-y. PMID 15014966. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (2004). "Otubains: a new family of cysteine proteases in the ubiquitin pathway.". EMBO Rep. 4 (5): 517-22. doi:10.1038/sj.embor.embor824. PMID 12704427. 
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601-7. doi:10.1038/nature01348. PMID 12508121. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
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