OTUB1

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OTU domain, ubiquitin aldehyde binding 1
Identifiers
Symbol(s) OTUB1; FLJ20113; FLJ40710; HSPC263; MGC111158; MGC4584; OTB1; OTU1
External IDs OMIM: 608337 MGI: 2147616 HomoloGene: 9772
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55611 107260
Ensembl ENSG00000167770 ENSMUSG00000024767
Uniprot Q96FW1 Q7TQI3
Refseq NM_017670 (mRNA)
NP_060140 (protein)		 XM_986327 (mRNA)
XP_991421 (protein)
Location Chr 11: 63.51 - 63.52 Mb Chr 19: 7.27 - 7.27 Mb
Pubmed search [1] [2]

OTU domain, ubiquitin aldehyde binding 1, also known as OTUB1, is a human gene.[1]

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.[1]

[edit] References

  1. ^ a b Entrez Gene: OTUB1 OTU domain, ubiquitin aldehyde binding 1.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Makarova KS, Aravind L, Koonin EV (2000). "A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae.". Trends Biochem. Sci. 25 (2): 50–2. PMID 10664582. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152. 
  • Borodovsky A, Ovaa H, Kolli N, et al. (2003). "Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.". Chem. Biol. 9 (10): 1149–59. PMID 12401499. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (2004). "Otubains: a new family of cysteine proteases in the ubiquitin pathway.". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMID 12704427. 
  • Soares L, Seroogy C, Skrenta H, et al. (2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL.". Nat. Immunol. 5 (1): 45–54. doi:10.1038/ni1017. PMID 14661020. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Juris SJ, Shah K, Shokat K, et al. (2006). "Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry.". FEBS Lett. 580 (1): 179–83. doi:10.1016/j.febslet.2005.11.071. PMID 16364312. 
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