OSBPL2

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Oxysterol binding protein-like 2
Identifiers
Symbol(s) OSBPL2; FLJ20223; KIAA0772; MGC4307; MGC8342; ORP-2; ORP2
External IDs OMIM: 606731 MGI: 2442832 HomoloGene: 77324
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9885 228983
Ensembl ENSG00000130703 ENSMUSG00000039050
Uniprot Q9H1P3 Q3TDA1
Refseq NM_014835 (mRNA)
NP_055650 (protein)		 NM_144500 (mRNA)
NP_653083 (protein)
Location Chr 20: 60.25 - 60.3 Mb Chr 2: 180.05 - 180.09 Mb
Pubmed search [1] [2]

Oxysterol binding protein-like 2, also known as OSBPL2, is a human gene.[1]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.[1]

[edit] References

  1. ^ a b Entrez Gene: OSBPL2 oxysterol binding protein-like 2.

[edit] Further reading

  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452. 
  • Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.". J. Lipid Res. 40 (12): 2204–11. PMID 10588946. 
  • Xu Y, Liu Y, Ridgway ND, McMaster CR (2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport.". J. Biol. Chem. 276 (21): 18407–14. doi:10.1074/jbc.M101204200. PMID 11279184. 
  • Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans.". J. Lipid Res. 42 (8): 1203–13. PMID 11483621. 
  • Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains.". Genomics 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Laitinen S, Lehto M, Lehtonen S, et al. (2002). "ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism.". J. Lipid Res. 43 (2): 245–55. PMID 11861666. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
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