OSBPL1A
From Wikipedia, the free encyclopedia
Oxysterol binding protein-like 1A
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Identifiers | ||||||||||||||
Symbol(s) | OSBPL1A; ORP1; FLJ10217; ORP-1; OSBPL1B | |||||||||||||
External IDs | OMIM: 606730 MGI: 1927551 HomoloGene: 84746 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 114876 | 64291 | ||||||||||||
Ensembl | ENSG00000141447 | ENSMUSG00000044252 | ||||||||||||
Uniprot | Q9BXW6 | Q8K2D2 | ||||||||||||
Refseq | NM_018030 (mRNA) NP_060500 (protein) |
NM_207530 (mRNA) NP_997413 (protein) |
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Location | Chr 18: 20 - 20.23 Mb | Chr 18: 12.9 - 13.09 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Oxysterol binding protein-like 1A, also known as OSBPL1A, is a human gene.[1]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.[1]
[edit] References
[edit] Further reading
- Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.". J. Lipid Res. 40 (12): 2204-11. PMID 10588946.
- Xu Y, Liu Y, Ridgway ND, McMaster CR (2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport.". J. Biol. Chem. 276 (21): 18407-14. doi: . PMID 11279184.
- Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans.". J. Lipid Res. 42 (8): 1203-13. PMID 11483621.
- Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains.". Genomics 78 (3): 185-96. doi: . PMID 11735225.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi: . PMID 12477932.
- Johansson M, Bocher V, Lehto M, et al. (2004). "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct.". Mol. Biol. Cell 14 (3): 903-15. doi: . PMID 12631712.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi: . PMID 14702039.
- Johansson M, Lehto M, Tanhuanpää K, et al. (2006). "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.". Mol. Biol. Cell 16 (12): 5480-92. doi: . PMID 16176980.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi: . PMID 17081983.