OSBPL1A

From Wikipedia, the free encyclopedia


Oxysterol binding protein-like 1A
Identifiers
Symbol(s) OSBPL1A; ORP1; FLJ10217; ORP-1; OSBPL1B
External IDs OMIM: 606730 MGI1927551 HomoloGene84746
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 114876 64291
Ensembl ENSG00000141447 ENSMUSG00000044252
Uniprot Q9BXW6 Q8K2D2
Refseq NM_018030 (mRNA)
NP_060500 (protein)
NM_207530 (mRNA)
NP_997413 (protein)
Location Chr 18: 20 - 20.23 Mb Chr 18: 12.9 - 13.09 Mb
Pubmed search [1] [2]

Oxysterol binding protein-like 1A, also known as OSBPL1A, is a human gene.[1]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.[1]

[edit] References

[edit] Further reading

  • Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.". J. Lipid Res. 40 (12): 2204-11. PMID 10588946. 
  • Xu Y, Liu Y, Ridgway ND, McMaster CR (2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport.". J. Biol. Chem. 276 (21): 18407-14. doi:10.1074/jbc.M101204200. PMID 11279184. 
  • Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans.". J. Lipid Res. 42 (8): 1203-13. PMID 11483621. 
  • Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains.". Genomics 78 (3): 185-96. doi:10.1006/geno.2001.6663. PMID 11735225. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Johansson M, Bocher V, Lehto M, et al. (2004). "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct.". Mol. Biol. Cell 14 (3): 903-15. doi:10.1091/mbc.E02-08-0459. PMID 12631712. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Johansson M, Lehto M, Tanhuanpää K, et al. (2006). "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.". Mol. Biol. Cell 16 (12): 5480-92. doi:10.1091/mbc.E05-03-0189. PMID 16176980. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.