OSBP2

From Wikipedia, the free encyclopedia


Oxysterol binding protein 2
Identifiers
Symbol(s) OSBP2; ORP-4; ORP4; OSBPL1; OSBPL4
External IDs OMIM: 606729 MGI: 1921559 HomoloGene: 75303
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23762 74309
Ensembl ENSG00000184792 ENSMUSG00000020435
Uniprot Q969R2 Q5F210
Refseq NM_030758 (mRNA)
NP_110385 (protein)		 XM_618841 (mRNA)
XP_618841 (protein)
Location Chr 22: 29.42 - 29.63 Mb Chr 11: 3.6 - 3.76 Mb
Pubmed search [1] [2]

Oxysterol binding protein 2, also known as OSBP2, is a human gene.[1]

Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.[1]

[edit] References

  1. ^ a b Entrez Gene: OSBP2 oxysterol binding protein 2.

[edit] Further reading

  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.". DNA Res. 8 (1): 1–9. PMID 11258795. 
  • Moreira EF, Jaworski C, Li A, Rodriguez IR (2001). "Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina.". J. Biol. Chem. 276 (21): 18570–8. doi:10.1074/jbc.M011259200. PMID 11278871. 
  • Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans.". J. Lipid Res. 42 (8): 1203–13. PMID 11483621. 
  • Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains.". Genomics 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225. 
  • Wang C, JeBailey L, Ridgway ND (2002). "Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments.". Biochem. J. 361 (Pt 3): 461–72. PMID 11802775. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Henriques Silva N, Vasconcellos Fournier M, Pimenta G, et al. (2004). "HLM/OSBP2 is expressed in chronic myeloid leukemia.". Int. J. Mol. Med. 12 (4): 663–6. PMID 12964051. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Wyles JP, Perry RJ, Ridgway ND (2007). "Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization.". Exp. Cell Res. 313 (7): 1426–37. doi:10.1016/j.yexcr.2007.01.018. PMID 17350617. 
 This article on a gene on chromosome 22 is a stub. You can help Wikipedia by expanding it.