ORM1

From Wikipedia, the free encyclopedia

Orosomucoid 1

Identifiers

ORM1; AGP1; ORM; AGP-A; AGP-B; AGP-B'; AGP2

External IDs

OMIM: 138600 MGI: 97445 HomoloGene: 88334

Gene ontology
Molecular Function:	• protein binding • binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• acute-phase response • inflammatory response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000607 (mRNA)
NP_000598 (protein)

NM_013623 (mRNA)
NP_038651 (protein)

Location

Chr 9: 116.13 - 116.13 Mb

Chr 4: 62.84 - 62.85 Mb

Pubmed search

[1]

[2]

Orosomucoid 1, also known as ORM1, is a human gene.^[1]

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.^[1]

[edit] See also

Orosomucoid

[edit] References

^ ^a ^b Entrez Gene: ORM1 orosomucoid 1.

[edit] Further reading

Treuheit MJ, Costello CE, Halsall HB (1992). "Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.". Biochem. J. 283 ( Pt 1): 105–12. PMID 1567356.
Dente L, Ciliberto G, Cortese R (1985). "Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.". Nucleic Acids Res. 13 (11): 3941–52. PMID 2409529.
Dubé JY, Paradis G, Têtu B, Tremblay RR (1989). "Synthesis of alpha 1-acid glycoprotein by the human prostate.". Prostate 15 (3): 251–8. PMID 2479939.
Zuffardi O, Caiulo A, Maraschio P, et al. (1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?". Hum. Genet. 82 (1): 17–9. PMID 2541064.
Dente L, Pizza MG, Metspalu A, Cortese R (1987). "Structure and expression of the genes coding for human alpha 1-acid glycoprotein.". EMBO J. 6 (8): 2289–96. PMID 2822385.
Merritt CM, Board PG (1988). "Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene.". Gene 66 (1): 97–106. PMID 2970990.
Dente L, Rüther U, Tripodi M, et al. (1988). "Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice.". Genes Dev. 2 (2): 259–66. PMID 3360326.
Rocchi M, Roncuzzi L, Santamaria R, et al. (1986). "Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9.". Hum. Genet. 74 (1): 30–3. PMID 3463531.
Board PG, Jones IM, Bentley AK (1986). "Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.". Gene 44 (1): 127–31. PMID 3770479.
Krauss E, Polnaszek CF, Scheeler DA, et al. (1987). "Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera.". J. Pharmacol. Exp. Ther. 239 (3): 754–9. PMID 3795040.
Ikenaka T, Ishiguro M, Emura J, et al. (1972). "Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.". Biochemistry 11 (20): 3817–29. PMID 4561179.
Schmid K, Bürgi W, Collins JH, Nanno S (1974). "The disulfide bonds of alpha1-acid glycoprotein.". Biochemistry 13 (13): 2694–7. PMID 4603214.
Schmid K, Kaufmann H, Isemura S, et al. (1973). "Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.". Biochemistry 12 (14): 2711–24. PMID 4711474.
Mbuyi JM, Dequeker J, Bloemmen F, Stevens E (1982). "Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE.". Calcif. Tissue Int. 34 (3): 229–31. PMID 6809283.
Rabehi L, Ferriere F, Saffar L, Gattegno L (1995). "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans.". Glycoconj. J. 12 (1): 7–16. PMID 7795416.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. PMID 8076819.
Nakamura T, Board PG, Matsushita K, et al. (1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis.". Inflammation 17 (1): 33–45. PMID 8432561.
Yuasa I, Umetsu K, Vogt U, et al. (1997). "Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.". Hum. Genet. 99 (3): 393–8. PMID 9050929.
Morin D, Simon N, Deprés-Brummer P, et al. (1997). "Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum.". Pharmacology 54 (5): 271–5. PMID 9380773.
Nakamura H, Yuasa I, Umetsu K, et al. (2000). "The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2.". Biochem. Biophys. Res. Commun. 276 (2): 779–84. doi:10.1006/bbrc.2000.3522. PMID 11027547.