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 To-do list for Orellanine: |
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- Expand article introduction
- Write about orellanine's light sensitivity
- Expand paragraph and explain how orellanine binds with alumunium ions
- Research and write more about treatment
- Explain the different types of orellanin, both the water soluble ones and the others
- Expand infobox
- Add information about the decomposition that occurs at 150 degrees celsius that causes orellanin to vaporize to oxygen leaving orellin behind.
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I added LD50 data, and a tiny bit of primary research: according to the literature, the LD50 of Cortinarius Speciocissimus and Orellanus mushrooms is 3 and 2 (freeze-dried) g/kg in mice. This would correspond to 30 and 20 g/kg for fresh mushrooms: more than 1 kg for an adult human. Only few mushroom hunters would eat their catch in such amounts, from which I conclude that either humans are more sensitive than mice, or it often takes more than 2 weeks to kill. I don't have enough background in toxicology to judge this. Han-Kwang 23:18, 6 July 2006 (UTC)
- The LD50 of pure Orellanine in mice is LD50 = 12.5 mg/kg intraperitoneally and LD50 = 90 mg/kg orally. I don't see any data on how much a adult human can ingest, but by reading incidents about Cortinarius poisoning it is obviously significantly less than 2kg. Most poisonings occur when a cortinarius mushroom has been accidently intermixed with other mushrooms and then ingested.
- The toxins latency time is extremely long regardless of the amount ingested it seems, in mice that were administered several times ld50 they still had a latency time > 2 days (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7195467&dopt=Citation). mic 01:00, 7 July 2006 (UTC)
- How is there no antidote? What about antioxidants? -lysdexia 02:47, 5 March 2007 (UTC)
- There is no direct antidote because the toxin, and how it works, is not completely understood. The anti-oxidant, like many other therapies, may help the body recover from the damage caused by the toxin but they don't counteract the poison. ([1] and [2])
