ORC4L

From Wikipedia, the free encyclopedia

Origin recognition complex, subunit 4-like (yeast)

Identifiers

ORC4L; ORC4; ORC4P

External IDs

OMIM: 603056 MGI: 1347043 HomoloGene: 8059

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • DNA replication origin binding • protein binding • ATP binding • nucleoside-triphosphatase activity
Cellular Component:	• nucleus
Biological Process:	• DNA replication • DNA replication initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002552 (mRNA)
NP_002543 (protein)

NM_011958 (mRNA)
NP_036088 (protein)

Location

Chr 2: 148.41 - 148.5 Mb

Chr 2: 48.72 - 48.77 Mb

Pubmed search

[1]

[2]

Origin recognition complex, subunit 4-like (yeast), also known as ORC4L, is a human gene.^[1]

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Quintana DG, Hou Zh, Thome KC, et al. (1997). "Identification of HsORC4, a member of the human origin of replication recognition complex.". J. Biol. Chem. 272 (45): 28247-51. PMID 9353276.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Eki T, Dean FB, Kohda A, et al. (1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22-->q23 by in situ hybridization and somatic cell hybrid analysis.". Cytogenet. Cell Genet. 81 (1): 89-90. PMID 9691185.
Tugal T, Zou-Yang XH, Gavin K, et al. (1999). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p.". J. Biol. Chem. 273 (49): 32421-9. PMID 9829972.
Springer J, Kneissl M, Pütter V, Grummt F (1999). "Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex.". Chromosoma 108 (4): 243-9. PMID 10460412.
Jiang W, McDonald D, Hope TJ, Hunter T (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.". EMBO J. 18 (20): 5703-13. doi:10.1093/emboj/18.20.5703. PMID 10523313.
Thome KC, Dhar SK, Quintana DG, et al. (2001). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins.". J. Biol. Chem. 275 (45): 35233-41. doi:10.1074/jbc.M005765200. PMID 10954718.
Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). "Assembly of the human origin recognition complex.". J. Biol. Chem. 276 (28): 26666-73. doi:10.1074/jbc.M102493200. PMID 11323433.
Dhar SK, Delmolino L, Dutta A (2001). "Architecture of the human origin recognition complex.". J. Biol. Chem. 276 (31): 29067-71. doi:10.1074/jbc.M103078200. PMID 11395502.
Okuno Y, McNairn AJ, den Elzen N, et al. (2001). "Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle.". EMBO J. 20 (15): 4263-77. doi:10.1093/emboj/20.15.4263. PMID 11483529.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.". J. Mol. Biol. 327 (1): 111-28. PMID 12614612.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Ramachandran N, Hainsworth E, Bhullar B, et al. (2004). "Self-assembling protein microarrays.". Science 305 (5680): 86-90. doi:10.1126/science.1097639. PMID 15232106.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Sibani S, Price GB, Zannis-Hadjopoulos M (2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex.". Biochemistry 44 (21): 7885-96. doi:10.1021/bi047327n. PMID 15910003.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.