ORC3L

From Wikipedia, the free encyclopedia

Origin recognition complex, subunit 3-like (yeast)

Identifiers

ORC3L; LAT; LATHEO; ORC3

External IDs

OMIM: 604972 MGI: 1354944 HomoloGene: 8225

Gene ontology
Molecular Function:	• DNA binding • DNA replication origin binding • protein binding
Cellular Component:	• nucleus • nuclear origin of replication recognition complex
Biological Process:	• DNA replication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012381 (mRNA)
NP_036513 (protein)

NM_015824 (mRNA)
NP_056639 (protein)

Location

Chr 6: 88.36 - 88.43 Mb

Chr 4: 34.76 - 34.8 Mb

Pubmed search

[1]

[2]

Origin recognition complex, subunit 3-like (yeast), also known as ORC3L, is a human gene.^[1]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Tugal T, Zou-Yang XH, Gavin K, et al. (1999). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p.". J. Biol. Chem. 273 (49): 32421–9. PMID 9829972.
Pinto S, Quintana DG, Smith P, et al. (1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant.". Neuron 23 (1): 45–54. PMID 10402192.
Springer J, Nanda I, Hoehn K, et al. (2000). "Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex.". Cytogenet. Cell Genet. 87 (3-4): 245–51. PMID 10702681.
Thome KC, Dhar SK, Quintana DG, et al. (2001). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins.". J. Biol. Chem. 275 (45): 35233–41. doi:10.1074/jbc.M005765200. PMID 10954718.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). "Assembly of the human origin recognition complex.". J. Biol. Chem. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.
Dhar SK, Delmolino L, Dutta A (2001). "Architecture of the human origin recognition complex.". J. Biol. Chem. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.". J. Mol. Biol. 327 (1): 111–28. PMID 12614612.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ramachandran N, Hainsworth E, Bhullar B, et al. (2004). "Self-assembling protein microarrays.". Science 305 (5680): 86–90. doi:10.1126/science.1097639. PMID 15232106.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sibani S, Price GB, Zannis-Hadjopoulos M (2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex.". Biochemistry 44 (21): 7885–96. doi:10.1021/bi047327n. PMID 15910003.
Matsuoka S, Ballif BA, Smogorzewska A, et al. (2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.". Science 316 (5828): 1160–6. doi:10.1126/science.1140321. PMID 17525332.