ORC2L

From Wikipedia, the free encyclopedia

Origin recognition complex, subunit 2-like (yeast)

Identifiers

External IDs

OMIM: 601182 MGI: 1328306 HomoloGene: 4512

Gene ontology
Molecular Function:	• DNA replication origin binding • protein binding
Cellular Component:	• chromatin • inner kinetochore of condensed chromosome • nucleus • nuclear origin of replication recognition complex
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • DNA replication • DNA replication initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006190 (mRNA)
NP_006181 (protein)

NM_001025378 (mRNA)
NP_001020549 (protein)

Location

Chr 2: 201.48 - 201.54 Mb

Chr 1: 58.41 - 58.45 Mb

Pubmed search

[1]

[2]

Origin recognition complex, subunit 2-like (yeast), also known as ORC2L, is a human gene.^[1]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3L, -4L, and -5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.^[1]

[edit] References

^ ^a ^b Entrez Gene: ORC2L origin recognition complex, subunit 2-like (yeast).

[edit] Further reading

Gavin KA, Hidaka M, Stillman B (1996). "Conserved initiator proteins in eukaryotes.". Science 270 (5242): 1667-71. PMID 7502077.
Takahara K, Bong M, Brevard R, et al. (1996). "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L.". Genomics 31 (1): 119-22. doi:10.1006/geno.1996.0018. PMID 8808289.
Quintana DG, Hou Zh, Thome KC, et al. (1997). "Identification of HsORC4, a member of the human origin of replication recognition complex.". J. Biol. Chem. 272 (45): 28247-51. PMID 9353276.
Saha P, Thome KC, Yamaguchi R, et al. (1998). "The human homolog of Saccharomyces cerevisiae CDC45.". J. Biol. Chem. 273 (29): 18205-9. PMID 9660782.
Ritzi M, Baack M, Musahl C, et al. (1998). "Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin.". J. Biol. Chem. 273 (38): 24543-9. PMID 9733749.
Quintana DG, Thome KC, Hou ZH, et al. (1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.". J. Biol. Chem. 273 (42): 27137-45. PMID 9765232.
Pinto S, Quintana DG, Smith P, et al. (1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant.". Neuron 23 (1): 45-54. PMID 10402192.
Jiang W, McDonald D, Hope TJ, Hunter T (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.". EMBO J. 18 (20): 5703-13. doi:10.1093/emboj/18.20.5703. PMID 10523313.
Natale DA, Li CJ, Sun WH, DePamphilis ML (2000). "Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals.". EMBO J. 19 (11): 2728-38. doi:10.1093/emboj/19.11.2728. PMID 10835370.
Thome KC, Dhar SK, Quintana DG, et al. (2001). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins.". J. Biol. Chem. 275 (45): 35233-41. doi:10.1074/jbc.M005765200. PMID 10954718.
Izumi M, Yanagi K, Mizuno T, et al. (2001). "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.". Nucleic Acids Res. 28 (23): 4769-77. PMID 11095689.
Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). "Assembly of the human origin recognition complex.". J. Biol. Chem. 276 (28): 26666-73. doi:10.1074/jbc.M102493200. PMID 11323433.
Dhar SK, Delmolino L, Dutta A (2001). "Architecture of the human origin recognition complex.". J. Biol. Chem. 276 (31): 29067-71. doi:10.1074/jbc.M103078200. PMID 11395502.
Dhar SK, Yoshida K, Machida Y, et al. (2001). "Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin.". Cell 106 (3): 287-96. PMID 11509178.
Izumi M, Yatagai F, Hanaoka F (2002). "Cell cycle-dependent proteolysis and phosphorylation of human Mcm10.". J. Biol. Chem. 276 (51): 48526-31. doi:10.1074/jbc.M107190200. PMID 11602595.
Fujita M, Ishimi Y, Nakamura H, et al. (2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells.". J. Biol. Chem. 277 (12): 10354-61. doi:10.1074/jbc.M111398200. PMID 11779870.
Schaarschmidt D, Ladenburger EM, Keller C, Knippers R (2002). "Human Mcm proteins at a replication origin during the G1 to S phase transition.". Nucleic Acids Res. 30 (19): 4176-85. PMID 12364596.
Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.". Biochim. Biophys. Acta 1578 (1-3): 59-72. PMID 12393188.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.". J. Mol. Biol. 327 (1): 111-28. PMID 12614612.