OR4C12

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Olfactory receptor, family 4, subfamily C, member 12
Identifiers
Symbol(s) OR4C12; OR11-259
External IDs MGI3031089 HomoloGene82298
Orthologs
Human Mouse
Entrez 283093 258979
Ensembl ENSG00000186419 ENSMUSG00000045148
Uniprot Q96R67 n/a
Refseq NM_001005270 (mRNA)
NP_001005270 (protein)
NM_146977 (mRNA)
NP_667188 (protein)
Location Chr 11: 49.96 - 49.96 Mb Chr 2: 89.62 - 89.62 Mb
Pubmed search [1] [2]

Olfactory receptor, family 4, subfamily C, member 12, also known as OR4C12, is a human gene.[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

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[edit] Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295–302. PMID 12213199. 
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. PMID 14983052. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.