OR3A3
From Wikipedia, the free encyclopedia
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Olfactory receptor, family 3, subfamily A, member 3
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| Identifiers | ||||||||||||||
| Symbol(s) | OR3A3; OR17-137; OR17-16; OR17-201; OR3A6; OR3A7; OR3A8P | |||||||||||||
| External IDs | MGI: 3030245 HomoloGene: 74999 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 8392 | 258704 | ||||||||||||
| Ensembl | ENSG00000159961 | ENSMUSG00000054406 | ||||||||||||
| Uniprot | P47888 | n/a | ||||||||||||
| Refseq | NM_012373 (mRNA) NP_036505 (protein) |
NM_146709 (mRNA) NP_666920 (protein) |
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| Location | Chr 17: 3.27 - 3.27 Mb | Chr 11: 74.16 - 74.16 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Olfactory receptor, family 3, subfamily A, member 3, also known as OR3A3, is a human gene.[1]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045–9. doi:. PMID 16625196.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. PMID 14983052.
- Gilad Y, Lancet D (2003). "Population differences in the human functional olfactory repertoire.". Mol. Biol. Evol. 20 (3): 307–14. PMID 12644552.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295–302. PMID 12213199.
- Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.". Genomics 63 (2): 227–45. doi:. PMID 10673334.
- Rouquier S, Taviaux S, Trask BJ, et al. (1998). "Distribution of olfactory receptor genes in the human genome.". Nat. Genet. 18 (3): 243–50. doi:. PMID 9500546.
- Ben-Arie N, Lancet D, Taylor C, et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.". Hum. Mol. Genet. 3 (2): 229–35. PMID 8004088.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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