OPN1SW

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Opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
Identifiers
Symbol(s) OPN1SW; BCP; BOP; CBT
External IDs OMIM: 190900 MGI: 99438 HomoloGene: 1291
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 611 12057
Ensembl ENSG00000128617 ENSMUSG00000058831
Uniprot P03999 P51491
Refseq NM_001708 (mRNA)
NP_001699 (protein)		 NM_007538 (mRNA)
NP_031564 (protein)
Location Chr 7: 128.2 - 128.2 Mb Chr 6: 29.33 - 29.33 Mb
Pubmed search [1] [2]

Opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan), also known as OPN1SW, is a human gene.[1]


[edit] See also

[edit] References

  1. ^ Entrez Gene: OPN1SW opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan).

[edit] Further reading

  • Applebury ML, Hargrave PA (1987). "Molecular biology of the visual pigments.". Vision Res. 26 (12): 1881-95. PMID 3303660. 
  • Swanson WH, Cohen JM (2003). "Color vision.". Ophthalmology clinics of North America 16 (2): 179-203. PMID 12809157. 
  • Weitz CJ, Went LN, Nathans J (1992). "Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment.". Am. J. Hum. Genet. 51 (2): 444-6. PMID 1386496. 
  • Weitz CJ, Miyake Y, Shinzato K, et al. (1992). "Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin.". Am. J. Hum. Genet. 50 (3): 498-507. PMID 1531728. 
  • Oprian DD, Asenjo AB, Lee N, Pelletier SL (1992). "Design, chemical synthesis, and expression of genes for the three human color vision pigments.". Biochemistry 30 (48): 11367-72. PMID 1742276. 
  • Sarkar G, Sommer SS (1989). "Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity.". Science 244 (4902): 331-4. PMID 2565599. 
  • Nathans J, Thomas D, Hogness DS (1986). "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.". Science 232 (4747): 193-202. PMID 2937147. 
  • Nathans J, Piantanida TP, Eddy RL, et al. (1986). "Molecular genetics of inherited variation in human color vision.". Science 232 (4747): 203-10. PMID 3485310. 
  • Fitzgibbon J, Appukuttan B, Gayther S, et al. (1994). "Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32.". Hum. Genet. 93 (1): 79-80. PMID 8270261. 
  • Shimmin LC, Mai P, Li WH (1997). "Sequences and evolution of human and squirrel monkey blue opsin genes.". J. Mol. Evol. 44 (4): 378-82. PMID 9089077. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205. 
  • Gunther KL, Neitz J, Neitz M (2006). "A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect.". Vis. Neurosci. 23 (3-4): 403-9. doi:10.1017/S0952523806233169. PMID 16961973. 
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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened