Talk:Olney's lesions
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[edit] Discredited?
I'd like to see the paper you're talking about here where Olney discredits the link between dissociatives and Olney's lesions. This is important, and I've looked through the internet to find whatever this recent reversal is based on. If anyone knows, please elaborate on that. Jolb 02:21, 14 September 2006 (UTC)
However, Olney's Lesions have now been discredited by the original author of the paper as an attempt to scare people away from DXM abuse (false it has not been discredited or disproven)
I have just a very extensive research on that statement. Erowid (notable drug vault), his claimed that Olney's Lesion DOES occur [1]. It has been proven to occur in rats. A google search on Olney's Lesions and being discredited or disproved brought no results. Valoem talk 21:22, 14 September 2006 (UTC)
Thanks alot! I did some similar research, though, and I was confused. It seemed to me that test on rats was Olney's original research, and my understanding of the chronology seems to be that those tests on rats were the ones that Olney discredited. My reasoning for this was that Erowid is a pretty old site and their report on Olney's legions seems older than all of the references to Olney discrediting his original research (these all seem to be very recent.) Maybe I wasn't careful in reading Erowid, but I'd still like to find some more conclusive chronology. Jolb 22:30, 14 September 2006 (UTC)
I jumped the gun and did some research of my own. You can read what I found (with sources) on the article page. Jolb 23:00, 14 September 2006 (UTC)
[edit] Major Improvement
I think this is a significant improvement in the page. I feel that we've created a concise and objective resource about Olney's Lesions. Thanks, Valoem!
np anytime =D Valoem talk 03:04, 15 September 2006 (UTC)
[edit] Psychedelic
Your substitution of "serotonergic" for "psychedelic" isn't correct. For one, according to Psychoactive drug, THC is a psychedelic, and it does NOT act on the Serotonin systems. Secondly, I'm having a debate with Thoric, the creator of the diagram on that page, on Thoric's talk page about whether that the term "psychedelic" includes dissociatives like DXM and ketamine, the very drugs that DO cause Olney's lesions. Therefore, I'll change the title back. Otherwise, I like that edit.Jolb 03:25, 30 January 2007 (UTC)
[edit] About the Carliss Article
Hey, I reverted your edit because that Carliss article is already referenced in the text:
- However, oral administration of dextromethorphan does not cause vacuolization in rats' brains.[5]
More importantly, that study was particularly about ORAL administration of DXM, (making it more relevant for humans since they usually take DXM orally) which you left out of your edit. Jolb 23:45, 26 October 2007 (UTC)
[edit] Olney's life
Olney himself is now dying of amyotrophic lateral sclerosis, so whatever he might have been doing in his personal life to avoid neuronal degeneration and death didn't work very well. —Preceding unsigned comment added by 75.15.137.89 (talk) 17:36, 9 May 2008 (UTC)
- Whoops, wrong Dr Olney. My mistake. 75.15.137.89 (talk) 17:39, 9 May 2008 (UTC)
