Oligomycin
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| Oligomycin A | |
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| Other names | Oligomycin |
| Molecular formula | C45H74O11 |
| Identifiers | |
| CAS number | [1404-19-9] |
| PubChem | |
| EINECS number | |
| MeSH | |
| RTECS number | RK3325000 |
| Properties | |
| Molar mass | 791.062 g/mol |
| Hazards | |
| MSDS | MSDS at Fermentek |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Oligomycins are macrolides created by Streptomyces that can be poisonous to other organisms.
[edit] Function
They have use as antibiotics.
In addition, oligomycin inhibits ATP synthase by blocking its proton channel, which is necessary for oxidative phosphorylation of ADP to ATP (energy production). Electron transport stops but there is an increase in the proton gradient, and electron transport soon stops because of the difficulty of pumping any more protons against the steep gradient.
Administering oligomycin to an individual can result in very high levels of lactate accumulating in the blood and urine.[citation needed]
Oligomycin is an inhibitor of ATP synthase. In oxidative phosphorylation research, it is used to prevent state 3 (phosphorylating) respiration.
[edit] References
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