OGFR

From Wikipedia, the free encyclopedia

Opioid growth factor receptor

Identifiers

External IDs

OMIM: 606459 MGI: 1919325 HomoloGene: 7199

Gene ontology
Molecular Function:	• receptor activity • opioid receptor activity
Cellular Component:	• cellular_component • membrane
Biological Process:	• regulation of cell growth

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007346 (mRNA)
NP_031372 (protein)

NM_031373 (mRNA)
NP_113550 (protein)

Location

Chr 20: 60.91 - 60.92 Mb

Chr 2: 180.52 - 180.53 Mb

Pubmed search

[1]

[2]

Opioid growth factor receptor, also known as OGFR, is a human gene.^[1]

The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: OGFR opioid growth factor receptor.

[edit] Further reading

Zagon IS, Verderame MF, McLaughlin PJ (2002). "The biology of the opioid growth factor receptor (OGFr).". Brain Res. Brain Res. Rev. 38 (3): 351–76. PMID 11890982.
Zagon IS, Verderame MF, Allen SS, McLaughlin PJ (2000). "Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans.". Brain Res. 856 (1-2): 75–83. PMID 10677613.
Wu CJ, Yang XF, McLaughlin S, et al. (2000). "Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia.". J. Clin. Invest. 106 (5): 705–14. PMID 10974024.
Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen.". DNA Res. 7 (6): 357–66. PMID 11214971.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zagon IS, Ruth TB, Leure-duPree AE, et al. (2003). "Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea.". Brain Res. 967 (1-2): 37–47. PMID 12650964.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
McLaughlin PJ, Zagon IS (2006). "Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor.". Int. J. Oncol. 28 (6): 1577–83. PMID 16685459.
Zagon IS, McLaughlin PJ (2006). "Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers.". Int. J. Oncol. 29 (2): 489–94. PMID 16820893.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
McLaughlin PJ, Verderame MF, Hankins JL, Zagon IS (2007). "Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck.". Int. J. Mol. Med. 19 (3): 421–8. PMID 17273790.