ODF2

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Outer dense fiber of sperm tails 2
Identifiers
Symbol(s) ODF2; FLJ44866; MGC111096; MGC9034; ODF2/1; ODF2/2; ODF84
External IDs OMIM: 602015 MGI: 1098824 HomoloGene: 1907
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4957 18286
Ensembl ENSG00000136811 ENSMUSG00000026790
Refseq NM_002540 (mRNA)
NP_002531 (protein)		 XM_990936 (mRNA)
XP_996030 (protein)
Location Chr 9: 130.26 - 130.3 Mb Chr 2: 29.71 - 29.75 Mb
Pubmed search [1] [2]

Outer dense fiber of sperm tails 2, also known as ODF2, is a human gene.[1]

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of this gene; however, not all isoforms and variants have been fully described.[1]

[edit] References

  1. ^ a b Entrez Gene: ODF2 outer dense fiber of sperm tails 2.

[edit] Further reading

  • Kierszenbaum AL (2002). "Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells.". Mol. Reprod. Dev. 61 (1): 1–2. doi:10.1002/mrd.1124. PMID 11774369. 
  • Shao X, Tarnasky HA, Schalles U, et al. (1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27.". J. Biol. Chem. 272 (10): 6105–13. PMID 9045620. 
  • Hoyer-Fender S, Petersen C, Brohmann H, et al. (1999). "Mouse Odf2 cDNAs consist of evolutionary conserved as well as highly variable sequences and encode outer dense fiber proteins of the sperm tail.". Mol. Reprod. Dev. 51 (2): 167–75. doi:10.1002/(SICI)1098-2795(199810)51:2<167::AID-MRD6>3.0.CO;2-O. PMID 9740324. 
  • Shao X, Murthy S, Demetrick DJ, van der Hoorn FA (1999). "Human outer dense fiber gene, ODF2, localizes to chromosome 9q34.". Cytogenet. Cell Genet. 83 (3-4): 221–3. PMID 10072582. 
  • Petersen C, Füzesi L, Hoyer-Fender S (1999). "Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa.". Mol. Hum. Reprod. 5 (7): 627–35. PMID 10381817. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Soung NK, Kang YH, Kim K, et al. (2007). "Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes.". Mol. Cell. Biol. 26 (22): 8316–35. doi:10.1128/MCB.00671-06. PMID 16966375. 
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