ODC1
From Wikipedia, the free encyclopedia
Ornithine decarboxylase 1
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PDB rendering based on 1d7k. | ||||||||||||||
Available structures: 1d7k, 7odc | ||||||||||||||
Identifiers | ||||||||||||||
Symbol(s) | ODC1; | |||||||||||||
External IDs | OMIM: 165640 MGI: 97402 HomoloGene: 1906 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 4953 | 18263 | ||||||||||||
Ensembl | ENSG00000115758 | ENSMUSG00000011179 | ||||||||||||
Uniprot | P11926 | Q3TM76 | ||||||||||||
Refseq | NM_002539 (mRNA) NP_002530 (protein) |
NM_013614 (mRNA) NP_038642 (protein) |
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Location | Chr 2: 10.5 - 10.51 Mb | Chr 12: 17.57 - 17.58 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Ornithine decarboxylase 1, also known as ODC1, is a human gene.
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.[1]
[edit] References
[edit] Further reading
- Pegg AE (2006). "Regulation of ornithine decarboxylase.". J. Biol. Chem. 281 (21): 14529–32. doi: . PMID 16459331.
- Yoshida M, Hayashi H, Taira M, Isono K (1992). "Elevated expression of the ornithine decarboxylase gene in human esophageal cancer.". Cancer Res. 52 (23): 6671–5. PMID 1423312.
- Moshier JA, Osborne DL, Skunca M, et al. (1992). "Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells.". Nucleic Acids Res. 20 (10): 2581–90. PMID 1598217.
- Hickok NJ, Wahlfors J, Crozat A, et al. (1990). "Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene.". Gene 93 (2): 257–63. PMID 2227439.
- Hsieh JT, Denning MF, Heidel SM, Verma AK (1990). "Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells.". Cancer Res. 50 (8): 2239–44. PMID 2317811.
- Moshier JA, Gilbert JD, Skunca M, et al. (1990). "Isolation and expression of a human ornithine decarboxylase gene.". J. Biol. Chem. 265 (9): 4884–92. PMID 2318872.
- Verrando P, Juhlin L, Lacour JP, Ortonne JP (1987). "Immunohistochemical localization of ornithine decarboxylase in human skin.". J. Dermatol. 14 (2): 112–7. PMID 2440930.
- van Steeg H, van Oostrom CT, Martens JW, et al. (1989). "Nucleotide sequence of the human ornithine decarboxylase gene.". Nucleic Acids Res. 17 (21): 8855–6. PMID 2587220.
- Fitzgerald MC, Flanagan MA (1990). "Characterization and sequence analysis of the human ornithine decarboxylase gene.". DNA 8 (9): 623–34. PMID 2693021.
- Alhonen-Hongisto L, Leinonen P, Sinervirta R, et al. (1987). "Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification.". Biochem. J. 242 (1): 205–10. PMID 3036086.
- Kaczmarek L, Calabretta B, Ferrari S, de Riel JK (1987). "Cell-cycle-dependent expression of human ornithine decarboxylase.". J. Cell. Physiol. 132 (3): 545–51. doi: . PMID 3308908.
- Hickok NJ, Seppänen PJ, Gunsalus GL, Jänne OA (1987). "Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA.". DNA 6 (3): 179–87. PMID 3595418.
- Winqvist R, Mäkelä TP, Seppänen P, et al. (1986). "Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene.". Cytogenet. Cell Genet. 42 (3): 133–40. PMID 3755388.
- Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. PMID 7821789.
- Kim YJ, Pan H, Verma AK (1994). "Non-AP-1 tumor promoter 12-O-tetradecanoylphorbol-13-acetate-responsive sequences in the human ornithine decarboxylase gene.". Mol. Carcinog. 10 (3): 169–79. PMID 8043198.
- Müller M, Pajunen AE, Järvinen M, et al. (1994). "Immunohistochemical demonstration of L-ornithine decarboxylase enzyme protein in different areas of the developing human brain.". Dev. Neurosci. 15 (2): 87–93. PMID 8168440.
- Ichiba T, Matsufuji S, Miyazaki Y, et al. (1994). "Functional regions of ornithine decarboxylase antizyme.". Biochem. Biophys. Res. Commun. 200 (3): 1721–7. doi: . PMID 8185631.
- Wright PS, Cooper JR, Cross-Doersen DE, et al. (1996). "Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element.". Cell Growth Differ. 6 (9): 1097–102. PMID 8519686.
- Heiskala M, Zhang J, Hayashi S, et al. (1999). "Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation.". EMBO J. 18 (5): 1214–22. doi: . PMID 10064588.
- Pomidor MM, Cimildoro R, Lazatin B, et al. (2000). "Phosphorylated human keratinocyte ornithine decarboxylase is preferentially associated with insoluble cellular proteins.". Mol. Biol. Cell 10 (12): 4299–310. PMID 10588659.