OBP2A

From Wikipedia, the free encyclopedia

Odorant binding protein 2A

Identifiers

OBP2A; OBP; OBP2C; OBPIIa; hOBPIIa

External IDs

OMIM: 164320 MGI: 2387617 HomoloGene: 87236

Gene ontology
Molecular Function:	• transporter activity • binding • odorant binding
Cellular Component:	• cellular_component
Biological Process:	• transport • sensory perception of smell • response to stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014582 (mRNA)
NP_055397 (protein)

NM_153558 (mRNA)
NP_705786 (protein)

Location

Chr 9: 137.58 - 137.58 Mb

Chr 2: 25.52 - 25.53 Mb

Pubmed search

[1]

[2]

Odorant binding protein 2A, also known as OBP2A, is a human gene.^[1]

This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: OBP2A odorant binding protein 2A.

[edit] Further reading

Tegoni M, Pelosi P, Vincent F, et al. (2000). "Mammalian odorant binding proteins.". Biochim. Biophys. Acta 1482 (1-2): 229–40. PMID 11058764.
Tcatchoff L, Nespoulous C, Pernollet JC, Briand L (2006). "A single lysyl residue defines the binding specificity of a human odorant-binding protein for aldehydes.". FEBS Lett. 580 (8): 2102–8. doi:10.1016/j.febslet.2006.03.017. PMID 16546182.
Breustedt DA, Schönfeld DL, Skerra A (2006). "Comparative ligand-binding analysis of ten human lipocalins.". Biochim. Biophys. Acta 1764 (2): 161–73. doi:10.1016/j.bbapap.2005.12.006. PMID 16461020.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matarazzo V, Zsürger N, Guillemot JC, et al. (2003). "Porcine odorant-binding protein selectively binds to a human olfactory receptor.". Chem. Senses 27 (8): 691–701. PMID 12379593.
Briand L, Eloit C, Nespoulous C, et al. (2002). "Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties.". Biochemistry 41 (23): 7241–52. PMID 12044155.
Lacazette E, Gachon AM, Pitiot G (2000). "A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres.". Hum. Mol. Genet. 9 (2): 289–301. PMID 10607840.