OAZ2

From Wikipedia, the free encyclopedia


Ornithine decarboxylase antizyme 2
Identifiers
Symbol(s) OAZ2;
External IDs OMIM: 604152 MGI: 109492 HomoloGene: 31094
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4947 18247
Ensembl ENSG00000180304 ENSMUSG00000040652
Uniprot O95190 O08608
Refseq NM_002537 (mRNA)
NP_002528 (protein)		 NM_010952 (mRNA)
NP_035082 (protein)
Location Chr 15: 62.77 - 62.77 Mb Chr 9: 65.47 - 65.49 Mb
Pubmed search [1] [2]

Ornithine decarboxylase antizyme 2, also known as OAZ2, is a human gene.[1]

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation.[1]

[edit] References

  1. ^ a b Entrez Gene: OAZ2 ornithine decarboxylase antizyme 2.

[edit] Further reading

  • Coffino P (2000). "Polyamines in spermiogenesis: not now, darling.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4421-3. PMID 10781034. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Mangold U, Leberer E (2005). "Regulation of all members of the antizyme family by antizyme inhibitor.". Biochem. J. 385 (Pt 1): 21-8. doi:10.1042/BJ20040547. PMID 15355308. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Chen H, MacDonald A, Coffino P (2003). "Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase.". J. Biol. Chem. 277 (48): 45957-61. doi:10.1074/jbc.M206799200. PMID 12359729. 
  • Zhou J, Atkins JF, Gesteland RF (1999). "Structure of human ornithine decarboxylase antizyme 2 gene.". Gene 232 (2): 165-71. PMID 10352227. 
  • Ivanov IP, Gesteland RF, Atkins JF (1998). "A second mammalian antizyme: conservation of programmed ribosomal frameshifting.". Genomics 52 (2): 119-29. doi:10.1006/geno.1998.5434. PMID 9782076. 
  • Nilsson J, Koskiniemi S, Persson K, et al. (1998). "Polyamines regulate both transcription and translation of the gene encoding ornithine decarboxylase antizyme in mouse.". Eur. J. Biochem. 250 (2): 223-31. PMID 9428668. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
 This article on a gene on chromosome 15 is a stub. You can help Wikipedia by expanding it.