O-succinylbenzoate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, an o-succinylbenzoate-CoA ligase (EC 6.2.1.26) is an enzyme that catalyzes the chemical reaction

ATP + o-succinylbenzoate + CoA $\rightleftharpoons$ AMP + diphosphate + o-succinylbenzoyl-CoA

The 3 substrates of this enzyme are ATP, o-succinylbenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and o-succinylbenzoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 2-succinylbenzoate:CoA ligase (AMP-forming). Other names in common use include 2-succinylbenzoyl-coenzyme A synthetase, and 2-succinylbenzoate:CoA ligase (AMP-forming). This enzyme participates in ubiquinone biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2OKT and 2OLA.

[edit] References

IUBMB entry for 6.2.1.26
BRENDA references for 6.2.1.26 (Recommended.)
PubMed references for 6.2.1.26
PubMed Central references for 6.2.1.26
Google Scholar references for 6.2.1.26
Heide L, Arendt S, Leistner E (1982). "Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis". J. Biol. Chem. 257: 7396–400. PMID 7045104.
Kolkmann R, Leistner E (1987). "4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis". Z. Naturforsch. [C]. 42: 1207–14. PMID 2966501.
Meganathan R, Bentley R (1979). "Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes". J. Bacteriol. 140: 92–8. PMID 500558.