O-acetylhomoserine aminocarboxypropyltransferase

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In enzymology, an O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) is an enzyme that catalyzes the chemical reaction

O-acetyl-L-homoserine + methanethiol $\rightleftharpoons$ L-methionine + acetate

Thus, the two substrates of this enzyme are O-acetyl-L-homoserine and methanethiol, whereas its two products are L-methionine and acetate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase. Other names in common use include O-acetyl-L-homoserine acetate-lyase (adding methanethiol), O-acetyl-L-homoserine sulfhydrolase, O-acetylhomoserine (thiol)-lyase, O-acetylhomoserine sulfhydrolase, and methionine synthase. This enzyme participates in methionine metabolism and cysteine metabolism.

[edit] References

IUBMB entry for 2.5.1.49
BRENDA references for 2.5.1.49 (Recommended.)
PubMed references for 2.5.1.49
PubMed Central references for 2.5.1.49
Google Scholar references for 2.5.1.49
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Yamagata S (1989). "Roles of O-acetyl-L-homoserine sulfhydrylases in micro-organisms". Biochimie. 71: 1125–43. PMID 2517474.
Kuramitsu S, Iwama T (2001). "Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product". Biochim. Biophys. Acta. 1549: 61–72. PMID 11566369.