NXF2

From Wikipedia, the free encyclopedia

Nuclear RNA export factor 2

Identifiers

NXF2; FLJ20416; TAPL-2

External IDs

OMIM: 300315 MGI: 2159343 HomoloGene: 88604

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • protein binding
Cellular Component:	• intracellular • nucleus • cytoplasm • nuclear RNA export factor complex
Biological Process:	• mRNA export from nucleus • transport • multicellular organismal development

Orthologs

Human

Mouse

n/a

Refseq

XM_001134413 (mRNA)
XP_001134413 (protein)

NM_130888 (mRNA)
NP_570958 (protein)

Location

n/a

Chr X: 130.93 - 130.94 Mb

Pubmed search

[1]

[2]

Nuclear RNA export factor 2, also known as NXF2, is a human gene.^[1]

This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: NXF2 nuclear RNA export factor 2.

[edit] Further reading

Black BE, Lévesque L, Holaska JM, et al. (2000). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.". Mol. Cell. Biol. 19 (12): 8616–24. PMID 10567585.
Herold A, Suyama M, Rodrigues JP, et al. (2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.". Mol. Cell. Biol. 20 (23): 8996–9008. PMID 11073998.
Wang PJ, McCarrey JR, Yang F, Page DC (2001). "An abundance of X-linked genes expressed in spermatogonia.". Nat. Genet. 27 (4): 422–6. doi:10.1038/86927. PMID 11279525.
Jun L, Frints S, Duhamel H, et al. (2002). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation.". Curr. Biol. 11 (18): 1381–91. PMID 11566096.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.