NXF1

From Wikipedia, the free encyclopedia

Nuclear RNA export factor 1

Available structures: 1fo1, 1ft8, 1go5, 1jkg, 1jn5, 1koh, 1koo, 1oai

Identifiers

NXF1; TAP; DKFZp667O0311; MEX67

External IDs

OMIM: 602647 MGI: 1858330 HomoloGene: 38176

Gene ontology
Molecular Function:	• nucleotide binding • mRNA binding • nucleocytoplasmic transporter activity • protein binding
Cellular Component:	• intracellular • nucleus • nuclear pore • nuclear inclusion body
Biological Process:	• RNA export from nucleus • transport • poly(A)+ mRNA export from nucleus • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001081491 (mRNA)
NP_001074960 (protein)

NM_016813 (mRNA)
NP_058093 (protein)

Location

Chr 11: 62.32 - 62.33 Mb

Chr 19: 8.82 - 8.84 Mb

Pubmed search

[1]

[2]

Nuclear RNA export factor 1, also known as NXF1, is a human gene.

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.^[1]