NUPL2

From Wikipedia, the free encyclopedia

Nucleoporin like 2

Identifiers

NUPL2; CG1; NLP-1; NLP_1; hCG1

External IDs

Gene ontology
Molecular Function:	• nucleic acid binding • nuclear export signal receptor activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • nuclear pore
Biological Process:	• protein export from nucleus • protein transport • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007342 (mRNA)
NP_031368 (protein)

NM_153092 (mRNA)
NP_694732 (protein)

Location

Chr 7: 23.19 - 23.21 Mb

Chr 5: 23.68 - 23.69 Mb

Pubmed search

[1]

[2]

Nucleoporin like 2, also known as NUPL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: NUPL2 nucleoporin like 2.

[edit] Further reading

Van Laer L, Van Camp G, van Zuijlen D, et al. (1998). "Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea.". Eur. J. Hum. Genet. 5 (6): 397–405. PMID 9450185.
Fouchier RA, Meyer BE, Simon JH, et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.". J. Virol. 72 (7): 6004–13. PMID 9621063.
Katahira J, Strässer K, Podtelejnikov A, et al. (1999). "The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.". EMBO J. 18 (9): 2593–609. doi:10.1093/emboj/18.9.2593. PMID 10228171.
Farjot G, Sergeant A, Mikaélian I (1999). "A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1.". J. Biol. Chem. 274 (24): 17309–17. PMID 10358091.
Strahm Y, Fahrenkrog B, Zenklusen D, et al. (1999). "The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p.". EMBO J. 18 (20): 5761–77. doi:10.1093/emboj/18.20.5761. PMID 10610322.
de Noronha CM, Sherman MP, Lin HW, et al. (2001). "Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr.". Science 294 (5544): 1105–8. doi:10.1126/science.1063957. PMID 11691994.
Le Rouzic E, Mousnier A, Rustum C, et al. (2003). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.". J. Biol. Chem. 277 (47): 45091–8. doi:10.1074/jbc.M207439200. PMID 12228227.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sasaki M, Takeda E, Takano K, et al. (2005). "Molecular cloning and functional characterization of mouse Nxf family gene products.". Genomics 85 (5): 641–53. doi:10.1016/j.ygeno.2005.01.003. PMID 15820316.
Kendirgi F, Rexer DJ, Alcázar-Román AR, et al. (2006). "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA.". Mol. Biol. Cell 16 (9): 4304–15. doi:10.1091/mbc.E04-11-0998. PMID 16000379.
Deniaud A, Brenner C, Kroemer G (2005). "Mitochondrial membrane permeabilization by HIV-1 Vpr.". Mitochondrion 4 (2-3): 223–33. doi:10.1016/j.mito.2004.06.012. PMID 16120388.