NUPL1

From Wikipedia, the free encyclopedia

Nucleoporin like 1

PDB rendering based on 2osz.

Available structures: 2osz

Identifiers

Symbol(s)

NUPL1; KIAA0410; PRO2463

External IDs

OMIM: 607615 MGI: 1919094 HomoloGene: 40924

Gene ontology
Molecular Function:	• serine-type endopeptidase inhibitor activity • protein binding
Cellular Component:	• nucleus
Biological Process:	• transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001008564 (mRNA)
NP_001008564 (protein)

NM_170591 (mRNA)
NP_733479 (protein)

Location

Chr 13: 24.77 - 24.81 Mb

Chr 14: 59.17 - 59.21 Mb

Pubmed search

[1]

[2]

Nucleoporin like 1, also known as NUPL1, is a human gene.^[1]

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: NUPL1 nucleoporin like 1.

[edit] Further reading

Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62.". J. Cell Biol. 128 (3): 251–61. PMID 7531196.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. PMID 9455477.
Ben-Efraim I, Gerace L (2001). "Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import.". J. Cell Biol. 152 (2): 411–7. PMID 11266456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.