NUP85

From Wikipedia, the free encyclopedia

Nucleoporin 85kDa

Identifiers

NUP85; FLJ12549; Nup75

External IDs

OMIM: 170285 MGI: 3046173 HomoloGene: 11755

Gene ontology
Molecular Function:	• protein binding • porin activity
Cellular Component:	• plasma membrane • integral to membrane • outer membrane
Biological Process:	• cytokine and chemokine mediated signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024844 (mRNA)
NP_079120 (protein)

XM_981300 (mRNA)
XP_986394 (protein)

Location

Chr 17: 70.71 - 70.74 Mb

Chr 11: 115.38 - 115.4 Mb

Pubmed search

[1]

[2]

Nucleoporin 85kDa, also known as NUP85, is a human gene.^[1]

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.^[1]

[edit] References

^ ^a ^b Entrez Gene: NUP85 nucleoporin 85kDa.

[edit] Further reading

Kapeller R, Toker A, Cantley LC, Carpenter CL (1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.". J. Biol. Chem. 270 (43): 25985–91. PMID 7592789.
Tynan SH, Purohit A, Doxsey SJ, Vallee RB (2000). "Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin.". J. Biol. Chem. 275 (42): 32763–8. doi:10.1074/jbc.M001536200. PMID 10893222.
Cronshaw JM, Krutchinsky AN, Zhang W, et al. (2002). "Proteomic analysis of the mammalian nuclear pore complex.". J. Cell Biol. 158 (5): 915–27. doi:10.1083/jcb.200206106. PMID 12196509.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mulari MT, Patrikainen L, Kaisto T, et al. (2003). "The architecture of microtubular network and Golgi orientation in osteoclasts--major differences between avian and mammalian species.". Exp. Cell Res. 285 (2): 221–35. PMID 12706117.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.". Mol. Biol. Cell 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMID 14767062.
Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.". Mol. Biol. Cell 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMID 15146057.
Terashima Y, Onai N, Murai M, et al. (2005). "Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis.". Nat. Immunol. 6 (8): 827–35. doi:10.1038/ni1222. PMID 15995708.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Satoh M, Akatsu T, Ishkawa Y, et al. (2007). "A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart.". J. Card. Fail. 13 (2): 114–9. doi:10.1016/j.cardfail.2006.11.003. PMID 17395051.