NUP50

From Wikipedia, the free encyclopedia

Nucleoporin 50kDa

Identifiers

NUP50; MGC39961; NPAP60; NPAP60L

External IDs

OMIM: 604646 MGI: 1351502 HomoloGene: 5190

Gene ontology
Molecular Function:	• porin activity
Cellular Component:	• nucleus • nuclear pore • integral to membrane • outer membrane
Biological Process:	• protein transport • intracellular transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007172 (mRNA)
NP_009103 (protein)

NM_016714 (mRNA)
NP_057923 (protein)

Location

Chr 22: 43.94 - 43.96 Mb

Chr 15: 84.75 - 84.77 Mb

Pubmed search

[1]

[2]

Nucleoporin 50kDa, also known as NUP50, is a human gene.^[1]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: NUP50 nucleoporin 50kDa.

[edit] Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Swaminathan S, Melchior F (2002). "Nucleocytoplasmic transport: more than the usual suspects.". Dev. Cell 3 (3): 304–6. PMID 12361592.
Lindsay ME, Plafker K, Smith AE, et al. (2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import.". Cell 110 (3): 349–60. PMID 12176322.
Smitherman M, Lee K, Swanger J, et al. (2000). "Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex.". Mol. Cell. Biol. 20 (15): 5631–42. PMID 10891500.
Guan T, Kehlenbach RH, Schirmer EC, et al. (2000). "Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export.". Mol. Cell. Biol. 20 (15): 5619–30. PMID 10891499.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Trichet V, Shkolny D, Dunham I, et al. (1999). "Mapping and complex expression pattern of the human NPAP60L nucleoporin gene.". Cytogenet. Cell Genet. 85 (3-4): 221–6. PMID 10449902.