NUDT6

From Wikipedia, the free encyclopedia

Nudix (nucleoside diphosphate linked moiety X)-type motif 6

Identifiers

NUDT6; ASFGF2; FGF-2; FGF-AS; FGF2AS; bFGF; gfg; gfg-1

External IDs

OMIM: 606261 MGI: 2387618 HomoloGene: 31425

Gene ontology
Molecular Function:	• growth factor activity • hydrolase activity
Cellular Component:	• cellular_component
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007083 (mRNA)
NP_009014 (protein)

NM_153561 (mRNA)
NP_705789 (protein)

Location

Chr 4: 124.03 - 124.06 Mb

Chr 3: 37.6 - 37.61 Mb

Pubmed search

[1]

[2]

Nudix (nucleoside diphosphate linked moiety X)-type motif 6, also known as NUDT6, is a human gene.^[1]

FGF2 (MIM 134920) is a highly conserved, multifunctional heparin-binding growth factor involved in neuroectoderm development, angiogenesis, and wound healing. Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene, NUDT6, may regulate FGF2 expression.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6.

[edit] Further reading

Murphy PR, Knee RS (1995). "Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene.". Mol. Endocrinol. 8 (7): 852-9. PMID 7984147.
Knee RS, Pitcher SE, Murphy PR (1995). "Basic fibroblast growth factor sense (FGF) and antisense (gfg) RNA transcripts are expressed in unfertilized human oocytes and in differentiated adult tissues.". Biochem. Biophys. Res. Commun. 205 (1): 577-83. doi:10.1006/bbrc.1994.2704. PMID 7999082.
Li AW, Too CK, Knee R, et al. (1998). "FGF-2 antisense RNA encodes a nuclear protein with MutT-like antimutator activity.". Mol. Cell. Endocrinol. 133 (2): 177-82. PMID 9406864.
Gagnon ML, Moy GK, Klagsbrun M (1999). "Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells.". J. Cell. Biochem. 72 (4): 492-506. PMID 10022609.
Asa SL, Ramyar L, Murphy PR, et al. (2001). "The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production.". Mol. Endocrinol. 15 (4): 589-99. PMID 11266510.
Duplan SM, Théorêt Y, Kenigsberg RL (2002). "Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant.". Clin. Cancer Res. 8 (1): 246-57. PMID 11801566.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sheng Z, Lewis JA, Chirico WJ (2004). "Nuclear and nucleolar localization of 18-kDa fibroblast growth factor-2 is controlled by C-terminal signals.". J. Biol. Chem. 279 (38): 40153-60. doi:10.1074/jbc.M400123200. PMID 15247275.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells.". J. Proteome Res. 6 (1): 298-305. doi:10.1021/pr060438j. PMID 17203973.
Pezzatini S, Morbidelli L, Solito R, et al. (2007). "Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis.". Bone 41 (4): 523-34. doi:10.1016/j.bone.2007.06.016. PMID 17681892.