NUDT1

From Wikipedia, the free encyclopedia


Nudix (nucleoside diphosphate linked moiety X)-type motif 1
PDB rendering based on 1iry.
Available structures: 1iry
Identifiers
Symbol(s) NUDT1; MTH1
External IDs OMIM: 600312 MGI: 109280 HomoloGene: 1839
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4521 17766
Ensembl ENSG00000106268 ENSMUSG00000036639
Uniprot P36639 Q542J4
Refseq NM_002452 (mRNA)
NP_002443 (protein)		 NM_008637 (mRNA)
NP_032663 (protein)
Location Chr 7: 2.25 - 2.26 Mb Chr 5: 140.58 - 140.59 Mb
Pubmed search [1] [2]

Nudix (nucleoside diphosphate linked moiety X)-type motif 1, also known as NUDT1, is a human gene.[1]

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.[1]

[edit] References

  1. ^ a b Entrez Gene: NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1.

[edit] Further reading

  • Ponnambalam S, Jackson AP, LeBeau MM, et al. (1995). "Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB).". Genomics 24 (3): 440–4. doi:10.1006/geno.1994.1650. PMID 7713494. 
  • Furuichi M, Yoshida MC, Oda H, et al. (1995). "Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion.". Genomics 24 (3): 485–90. doi:10.1006/geno.1994.1657. PMID 7713500. 
  • Kang D, Nishida J, Iyama A, et al. (1995). "Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria.". J. Biol. Chem. 270 (24): 14659–65. PMID 7782328. 
  • Sakumi K, Furuichi M, Tsuzuki T, et al. (1993). "Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.". J. Biol. Chem. 268 (31): 23524–30. PMID 8226881. 
  • Oda H, Nakabeppu Y, Furuichi M, Sekiguchi M (1997). "Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products.". J. Biol. Chem. 272 (28): 17843–50. PMID 9211940. 
  • Oda H, Taketomi A, Maruyama R, et al. (1999). "Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism.". Nucleic Acids Res. 27 (22): 4335–43. PMID 10536140. 
  • Tsuzuki T, Egashira A, Igarashi H, et al. (2001). "Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11456–61. doi:10.1073/pnas.191086798. PMID 11572992. 
  • Sakai Y, Furuichi M, Takahashi M, et al. (2002). "A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.". J. Biol. Chem. 277 (10): 8579–87. doi:10.1074/jbc.M110566200. PMID 11756418. 
  • Fujikawa K, Yakushiji H, Nakabeppu Y, et al. (2002). "8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog.". FEBS Lett. 512 (1-3): 149–51. PMID 11852070. 
  • Topp H, Armbrust S, Lengger C, et al. (2002). "Renal excretion of 8-oxo-7,8-dihydro-2(')-deoxyguanosine: degradation rates of RNA and metabolic rate in humans.". Arch. Biochem. Biophys. 402 (1): 31–7. doi:10.1016/S0003-9861(02)00034-6. PMID 12051680. 
  • Takahashi M, Maraboeuf F, Sakai Y, et al. (2002). "Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein.". J. Mol. Biol. 319 (1): 129–39. PMID 12051941. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Liu Z, Wang LE, Strom SS, et al. (2003). "Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis.". Mol. Carcinog. 36 (3): 123–9. doi:10.1002/mc.10108. PMID 12619034. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. 
  • Ishibashi T, Hayakawa H, Sekiguchi M (2004). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.". EMBO Rep. 4 (5): 479–83. doi:10.1038/sj.embor.embor838. PMID 12717453. 
  • Kennedy CH, Pass HI, Mitchell JB (2004). "Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.". Free Radic. Biol. Med. 34 (11): 1447–57. PMID 12757855. 
  • Yoshimura D, Sakumi K, Ohno M, et al. (2003). "An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress.". J. Biol. Chem. 278 (39): 37965–73. doi:10.1074/jbc.M306201200. PMID 12857738. 
  • Kamiya H, Dugué L, Yakushiji H, et al. (2003). "Substrate recognition by the human MTH1 protein.". Nucleic Acids Res. Suppl. (2): 85–6. PMID 12903117. 
  • Bialkowski K, Kasprzak KS (2004). "Inhibition of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity of the antimutagenic human MTH1 protein by nucleoside 5'-diphosphates.". Free Radic. Biol. Med. 35 (6): 595–602. PMID 12957652. 
  • Kamiya H, Yakushiji H, Dugué L, et al. (2004). "Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs.". J. Mol. Biol. 336 (4): 843–50. doi:10.1016/j.jmb.2003.12.060. PMID 15095864. 
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