Talk:Nuclear pore
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Accroding to image from article there is nuclear basket (?= nucleoplasmic basket) and distal ring. --Snek01 09:07, 21 April 2006 (UTC)
[edit] Size of the pore
There are uncited numbers that specify the size of the NPC:
- The entire pore complex has a diameter of about 120 nm, the diameter of the opening is about 50 nm wide and its "depth" is about 200 nm.
I am sure these numbers vary greatly by organizm, but I found a paper on the frog oocytes sizes:
- Hinshaw JE, Carragher BO, Milligan RA. "Architecture and design of the nuclear pore complex." Cell. 1992 Jun 26;69(7):1133-41. PMID 1617726
where they state:
- "Stain penetration between the center and outer regions in each spoke, at a radius of ~465 A, correlates closely with the known radial position of the membrane (r = ~450 A) (Unwin and Milligan, 1982)." [10 A = 1 nm]
and also:
- "The rings have weak 8-fold symmetry and consist of a ~150 A-wide circle of mass centered at a radius of about ~450 A." [10 A = 1 nm]
so these numbers are very different than the ones in the wiki article.
--vossman 19:33, 4 April 2007 (UTC)
Oops, these number correlate pretty well. I forgot to do the radius to diameter conversion.
--vossman 20:04, 4 April 2007 (UTC)
[edit] Nuclear Pore directionality
Looking at the nuclear pore, it seems like the dangling cage at the bottom is a one-way gate: it is more likely for proteins to pass down than up. Could it be that the 2000 nuclear pores are oriented roughly half up and half down, allowing one-way traffic in and out of the nucleus? Has any research been done on this? —The preceding unsigned comment was added by Chrystomath (talk • contribs) 10:07, 27 April 2007 (UTC).
- No, all NPCs are oriented the same way and the asymmetry doesn't seem to be playing a major role in the transport. See for example: Zeitler, B. & Weis, K. (2004) J. Cell Biol 167, 583–590. [1] --GKiller (talk) 14:59, 8 March 2008 (UTC)
