Nucleoside analogues

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Nucleoside analogues are a range of antiviral products used to prevent viral replication in infected cells. The most commonly used is Aciclovir.

[edit] Function

They work as antimetabolites by being similar enough to nucleosides to be incorporated into growing DNA strands, but different enough ensure that the resultant DNA is non-functional. They also affect normal cell growth, such as bone marrow cells, so there can be significant toxic effects.

There is a large family of nucleoside analogue reverse transcriptase inhibitors, because DNA production by reverse transcriptase is very different from normal human DNA replication, so it is possible to design nucleoside analogues that are preferentially incorporated by the former.

Less selective nucleoside analogues are used as chemotherapy agents to treat cancer.

[edit] Examples

Nucleoside analogue drugs include:

• deoxyadenosine analogues
  • Didanosine
  • Vidarabine (chemotherapy)
• deoxycytidine analogues
  • Cytarabine (chemotherapy)
  • Emtricitabine
  • Lamivudine
  • Zalcitabine
• deoxyguanosine analogues
  • Abacavir
• (deoxy-)thymidine analogues
  • Stavudine
  • Zidovudine (Azidothymidine, or AZT)
• deoxyuridine analogues
  • Idoxuridine
  • Trifluridine

Related drugs are nucleobase analogues such as Aciclovir and nucleotide analogues.

[edit] See also

• For Nucleoside analogues in biology see Nucleic acid analogues

v • d • e Antivirals, other than for HIV (primarily J05, also S01AD and D06BB) Anti-herpesvirus (DNA, I) guanine analogues (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • nucleoside analogues (Idoxuridine, Trifluridine, Vidarabine) • Cidofovir • Docosanol • Fomivirsen • Foscarnet • Tromantadine HPV/MC (DNA, I) Imiquimod • Podophyllotoxin Hepatitis B (DNA, VII) Adefovir • Clevudine • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir† Hepatitis C (RNA, IV) Pegylated interferon alpha • Ribavirin • Taribavirin† • Boceprevir† Picornavirus (RNA, IV) Pleconaril† Anti-influenza agents (RNA, V) Arbidol adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir†) HIV (Reverse, VI) See HIV pharm Other antiviral agents general (Inosine, Interferon) †Undergoing clinical trials, not FDA approved.