Nucleolin

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Nucleolin
PDB rendering based on 2fc8.
Available structures: 2fc8, 2fc9
Identifiers
Symbol(s) NCL; C23; FLJ45706
External IDs OMIM: 164035 HomoloGene: 21821
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4691 n/a
Ensembl ENSG00000115053 n/a
Uniprot P19338 n/a
Refseq NM_005381 (mRNA)
NP_005372 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 2: 232.03 - 232.04 Mb n/a
Pubmed search [1] n/a

Nucleolin, also known as NCL, is a human gene.

Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.[1]

[edit] References

  1. ^ Entrez Gene: NCL nucleolin.

[edit] Further reading

  • Tuteja R, Tuteja N (1999). "Nucleolin: a multifunctional major nucleolar phosphoprotein.". Crit. Rev. Biochem. Mol. Biol. 33 (6): 407–36. PMID 9918513. 
  • Pasternack MS, Bleier KJ, McInerney TN (1991). "Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro.". J. Biol. Chem. 266 (22): 14703–8. PMID 1860869. 
  • Belenguer P, Caizergues-Ferrer M, Labbé JC, et al. (1990). "Mitosis-specific phosphorylation of nucleolin by p34cdc2 protein kinase.". Mol. Cell. Biol. 10 (7): 3607–18. PMID 2192260. 
  • Srivastava M, McBride OW, Fleming PJ, et al. (1990). "Genomic organization and chromosomal localization of the human nucleolin gene.". J. Biol. Chem. 265 (25): 14922–31. PMID 2394707. 
  • Srivastava M, Fleming PJ, Pollard HB, Burns AL (1989). "Cloning and sequencing of the human nucleolin cDNA.". FEBS Lett. 250 (1): 99–105. PMID 2737305. 
  • Erard MS, Belenguer P, Caizergues-Ferrer M, et al. (1988). "A major nucleolar protein, nucleolin, induces chromatin decondensation by binding to histone H1.". Eur. J. Biochem. 175 (3): 525–30. PMID 3409881. 
  • Tuteja N, Huang NW, Skopac D, et al. (1995). "Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylation.". Gene 160 (2): 143–8. PMID 7642087. 
  • Jordan P, Heid H, Kinzel V, Kübler D (1995). "Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins.". Biochemistry 33 (49): 14696–706. PMID 7993898. 
  • Nicoloso M, Caizergues-Ferrer M, Michot B, et al. (1994). "U20, a novel small nucleolar RNA, is encoded in an intron of the nucleolin gene in mammals.". Mol. Cell. Biol. 14 (9): 5766–76. PMID 8065311. 
  • Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR (1993). "Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n.". Mol. Cell. Biol. 13 (7): 4301–10. PMID 8321232. 
  • Eggert M, Möws CC, Tripier D, et al. (1996). "A fraction enriched in a novel glucocorticoid receptor-interacting protein stimulates receptor-dependent transcription in vitro.". J. Biol. Chem. 270 (51): 30755–9. PMID 8530516. 
  • Bharti AK, Olson MO, Kufe DW, Rubin EH (1996). "Identification of a nucleolin binding site in human topoisomerase I.". J. Biol. Chem. 271 (4): 1993–7. PMID 8567649. 
  • Li YP, Busch RK, Valdez BC, Busch H (1996). "C23 interacts with B23, a putative nucleolar-localization-signal-binding protein.". Eur. J. Biochem. 237 (1): 153–8. PMID 8620867. 
  • Li D, Dobrowolska G, Krebs EG (1996). "The physical association of casein kinase 2 with nucleolin.". J. Biol. Chem. 271 (26): 15662–8. PMID 8663258. 
  • Zhou G, Seibenhener ML, Wooten MW (1998). "Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells.". J. Biol. Chem. 272 (49): 31130–7. PMID 9388266. 
  • Haluska P, Saleem A, Edwards TK, Rubin EH (1998). "Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen.". Nucleic Acids Res. 26 (7): 1841–7. PMID 9512561. 
  • Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex.". J. Biol. Chem. 273 (27): 17025–35. PMID 9642267. 
  • Larrucea S, González-Rubio C, Cambronero R, et al. (1998). "Cellular adhesion mediated by factor J, a complement inhibitor. Evidence for nucleolin involvement.". J. Biol. Chem. 273 (48): 31718–25. PMID 9822633. 
  • Parada CA, Roeder RG (1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.". EMBO J. 18 (13): 3688–701. doi:10.1093/emboj/18.13.3688. PMID 10393184. 
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