From Wikipedia, the free encyclopedia
The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA1 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA1 assists nuclear receptors in the upregulation of DNA expression.[1][2]
NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).
[edit] External links
[edit] References
- ^ Onate SA, Tsai SY, Tsai MJ, O'Malley BW (1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science 270 (5240): 1354–7. doi:10.1126/science.270.5240.1354. PMID 7481822.
- ^ Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW (1998). "The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors". J Biol Chem 273 (20): 12101–8. doi:10.1074/jbc.273.20.12101. PMID 9575154.
[edit] Further reading
- Qi C, Zhu Y, Reddy JK (2001). "Peroxisome proliferator-activated receptors, coactivators, and downstream targets.". Cell Biochem. Biophys. 32 Spring: 187–204. PMID 11330046.
