Nuclear receptor co-repressor 2

From Wikipedia, the free encyclopedia


Nuclear receptor co-repressor 2
PDB rendering based on 1xc5.
Available structures: 1xc5
Identifiers
Symbol(s) NCOR2; CTG26; TNRC14; TRAC1; SMRT; SMRTE; SMRTE-tau; TRAC-1
External IDs OMIM: 600848 MGI1337080 HomoloGene31370
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 9612 20602
Ensembl ENSG00000196498 n/a
Uniprot Q9Y618 n/a
Refseq NM_001077261 (mRNA)
NP_001070729 (protein)
NM_011424 (mRNA)
NP_035554 (protein)
Location Chr 12: 123.37 - 123.55 Mb n/a
Pubmed search [1] [2]

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.[1][2]

NCOA2 is also sometimes referred to as silencing mediator for retinoid and thyroid-hormone receptors (SMRT) or T3 receptor-associating cofactor 1 (TRAC-1).

[edit] References

  1. ^ Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127. 
  2. ^ Sande S, Privalsky ML (1996). "Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors". Mol Endocrinol 10 (7): 813–25. doi:10.1210/me.10.7.813. PMID 8813722. 

[edit] External links

[edit] Further reading

  • Hörlein AJ, Näär AM, Heinzel T, et al. (1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.". Nature 377 (6548): 397–404. doi:10.1038/377397a0. PMID 7566114. 
  • Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors.". Nature 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127. 
  • Sande S, Privalsky ML (1997). "Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors.". Mol. Endocrinol. 10 (7): 813–25. PMID 8813722. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Margolis RL, Abraham MR, Gatchell SB, et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain.". Hum. Genet. 100 (1): 114–22. PMID 9225980. 
  • Hong SH, David G, Wong CW, et al. (1997). "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia.". Proc. Natl. Acad. Sci. U.S.A. 94 (17): 9028–33. PMID 9256429. 
  • Chen H, Lin RJ, Schiltz RL, et al. (1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.". Cell 90 (3): 569–80. PMID 9267036. 
  • Lin RJ, Nagy L, Inoue S, et al. (1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia.". Nature 391 (6669): 811–4. doi:10.1038/35895. PMID 9486654. 
  • Laherty CD, Billin AN, Lavinsky RM, et al. (1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.". Mol. Cell 2 (1): 33–42. PMID 9702189. 
  • Liu Y, Takeshita A, Misiti S, et al. (1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors.". Endocrinology 139 (10): 4197–204. PMID 9751500. 
  • Wong CW, Privalsky ML (1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6.". J. Biol. Chem. 273 (42): 27695–702. PMID 9765306. 
  • Ordentlich P, Downes M, Xie W, et al. (1999). "Unique forms of human and mouse nuclear receptor corepressor SMRT.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2639–44. PMID 10077563. 
  • Park EJ, Schroen DJ, Yang M, et al. (1999). "SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3519–24. PMID 10097068. 
  • Nguyen TA, Hoivik D, Lee JE, Safe S (1999). "Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.". Arch. Biochem. Biophys. 367 (2): 250–7. doi:10.1006/abbi.1999.1282. PMID 10395741. 
  • Bailey P, Downes M, Lau P, et al. (1999). "The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.". Mol. Endocrinol. 13 (7): 1155–68. PMID 10406466. 
  • Kao HY, Downes M, Ordentlich P, Evans RM (2000). "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression.". Genes Dev. 14 (1): 55–66. PMID 10640276. 
  • Zhou S, Fujimuro M, Hsieh JJ, et al. (2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.". Mol. Cell. Biol. 20 (7): 2400–10. PMID 10713164. 
  • Lee SK, Kim JH, Lee YC, et al. (2000). "Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor.". J. Biol. Chem. 275 (17): 12470–4. PMID 10777532. 
  • Guenther MG, Lane WS, Fischle W, et al. (2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.". Genes Dev. 14 (9): 1048–57. PMID 10809664. 
  • Grozinger CM, Schreiber SL (2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMID 10869435.