NUCB2

From Wikipedia, the free encyclopedia

Nucleobindin 2

Identifiers

External IDs

OMIM: 608020 MGI: 1858179 HomoloGene: 3676

Gene ontology
Molecular Function:	• DNA binding • calcium ion binding
Cellular Component:	• extracellular space • nucleus • nuclear outer membrane • cytoplasm • endoplasmic reticulum • ER-Golgi intermediate compartment • cytosol • plasma membrane

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005013 (mRNA)
NP_005004 (protein)

NM_016773 (mRNA)
NP_058053 (protein)

Location

Chr 11: 17.27 - 17.31 Mb

Chr 7: 116.31 - 116.33 Mb

Pubmed search

[1]

[2]

Nucleobindin 2, also known as NUCB2, is a human gene.^[1]

Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NUCB2 nucleobindin 2.

[edit] Further reading

Barnikol-Watanabe S, Gross NA, Götz H, et al. (1995). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein.". Biol. Chem. Hoppe-Seyler 375 (8): 497-512. PMID 7811391.
DeAngelis MM, Doucet JP, Drury S, et al. (1998). "Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene.". Biochim. Biophys. Acta 1407 (1): 84-91. PMID 9639681.
Kroll KA, Otte S, Hirschfeld G, et al. (1999). "Heterologous overexpression of human NEFA and studies on the two EF-hand calcium-binding sites.". Biochem. Biophys. Res. Commun. 260 (1): 1-8. doi:10.1006/bbrc.1999.0867. PMID 10381334.
Taniguchi N, Taniura H, Niinobe M, et al. (2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm.". J. Biol. Chem. 275 (41): 31674-81. doi:10.1074/jbc.M005103200. PMID 10915798.
Nesselhut J, Jurgan U, Onken E, et al. (2002). "Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region.". FEBS Lett. 509 (3): 469-75. PMID 11749975.
Linē A, Stengrēvics A, Slucka Z, et al. (2002). "Serological identification and expression analysis of gastric cancer-associated genes.". Br. J. Cancer 86 (11): 1824-30. doi:10.1038/sj.bjc.6600321. PMID 12087473.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.". J. Biol. Chem. 279 (45): 47242-53. doi:10.1074/jbc.M406644200. PMID 15308636.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Islam A, Adamik B, Hawari FI, et al. (2006). "Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex.". J. Biol. Chem. 281 (10): 6860-73. doi:10.1074/jbc.M509397200. PMID 16407280.