NUAK2

From Wikipedia, the free encyclopedia

NUAK family, SNF1-like kinase, 2

Identifiers

NUAK2; DKFZP434J037; DKFZp686F01113; FLJ90349; SNARK

External IDs

OMIM: 608131 MGI: 1921387 HomoloGene: 12539

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• nuclear speck
Biological Process:	• protein amino acid phosphorylation • apoptosis • actin cytoskeleton organization and biogenesis • cellular response to glucose starvation • negative regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030952 (mRNA)
NP_112214 (protein)

NM_028778 (mRNA)
NP_083054 (protein)

Location

Chr 1: 203.54 - 203.56 Mb

Chr 1: 134.14 - 134.16 Mb

Pubmed search

[1]

[2]

NUAK family, SNF1-like kinase, 2, also known as NUAK2, is a human gene.^[1]

[edit] References

^ Entrez Gene: NUAK2 NUAK family, SNF1-like kinase, 2.

[edit] Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Lefebvre DL, Bai Y, Shahmolky N, et al. (2001). "Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK.". Biochem. J. 355 (Pt 2): 297–305. PMID 11284715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Suzuki A, Kusakai G, Kishimoto A, et al. (2004). "Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family.". Biochem. Biophys. Res. Commun. 311 (1): 156–61. PMID 14575707.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMID 14976552.
Legembre P, Schickel R, Barnhart BC, Peter ME (2004). "Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness.". J. Biol. Chem. 279 (45): 46742–7. doi:10.1074/jbc.M404334200. PMID 15345718.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.