NUAK1

From Wikipedia, the free encyclopedia

NUAK family, SNF1-like kinase, 1

Identifiers

NUAK1; ARK5; KIAA0537

External IDs

OMIM: 608130 MGI: 1925226 HomoloGene: 8896

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation

Orthologs

Human

Mouse

n/a

n/a

Refseq

XM_001128097 (mRNA)
XP_001128097 (protein)

NM_001004363 (mRNA)
NP_001004363 (protein)

Location

n/a

Chr 10: 83.8 - 83.87 Mb

Pubmed search

[1]

[2]

NUAK family, SNF1-like kinase, 1, also known as NUAK1, is a human gene.^[1]

[edit] References

^ Entrez Gene: NUAK1 NUAK family, SNF1-like kinase, 1.

[edit] Further reading

Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31-9. PMID 9628581.
Suzuki A, Kusakai G, Kishimoto A, et al. (2003). "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein.". J. Biol. Chem. 278 (1): 48-53. doi:10.1074/jbc.M206025200. PMID 12409306.
Suzuki A, Kusakai G, Kishimoto A, et al. (2003). "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation.". Oncogene 22 (40): 6177-82. doi:10.1038/sj.onc.1206899. PMID 13679856.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.". EMBO J. 23 (4): 833-43. doi:10.1038/sj.emboj.7600110. PMID 14976552.
Suzuki A, Lu J, Kusakai G, et al. (2004). "ARK5 is a tumor invasion-associated factor downstream of Akt signaling.". Mol. Cell. Biol. 24 (8): 3526-35. PMID 15060171.
Suzuki A, Kusakai G, Kishimoto A, et al. (2004). "Regulation of caspase-6 and FLIP by the AMPK family member ARK5.". Oncogene 23 (42): 7067-75. doi:10.1038/sj.onc.1207963. PMID 15273717.
Kusakai G, Suzuki A, Ogura T, et al. (2005). "Strong association of ARK5 with tumor invasion and metastasis.". J. Exp. Clin. Cancer Res. 23 (2): 263-8. PMID 15354411.
Suzuki A, Iida S, Kato-Uranishi M, et al. (2006). "ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma.". Oncogene 24 (46): 6936-44. doi:10.1038/sj.onc.1208844. PMID 16044163.
Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.". J. Cell. Sci. 118 (Pt 23): 5661-73. doi:10.1242/jcs.02670. PMID 16306228.
Suzuki A, Ogura T, Esumi H (2006). "NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.". J. Biol. Chem. 281 (20): 13915-21. doi:10.1074/jbc.M511354200. PMID 16488889.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.