NTRK3

From Wikipedia, the free encyclopedia

Neurotrophic tyrosine kinase, receptor, type 3

PDB rendering based on 1wwc.

Available structures: 1wwc

Identifiers

Symbol(s)

NTRK3; TRKC; gp145(trkC)

External IDs

OMIM: 191316 MGI: 97385 HomoloGene: 49183

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • receptor activity • protein binding • ATP binding • kinase activity • transferase activity • neurotrophin binding
Cellular Component:	• cytoplasm • integral to plasma membrane • membrane
Biological Process:	• protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • multicellular organismal development • nervous system development • mechanoreceptor differentiation • positive regulation of axon extension involved in regeneration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001007156 (mRNA)
NP_001007157 (protein)

XM_979968 (mRNA)
XP_985062 (protein)

Location

Chr 15: 86.22 - 86.6 Mb

Chr 7: 78.07 - 78.45 Mb

Pubmed search

[1]

[2]

Neurotrophic tyrosine kinase, receptor, type 3, also known as NTRK3, is a human gene.

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.^[1]

[edit] References

^ Entrez Gene: NTRK3 neurotrophic tyrosine kinase, receptor, type 3.

[edit] Further reading

Ebendal T (1992). "Function and evolution in the NGF family and its receptors.". J. Neurosci. Res. 32 (4): 461-70. doi:10.1002/jnr.490320402. PMID 1326636.
Lamballe F, Klein R, Barbacid M (1991). "trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3.". Cell 66 (5): 967-79. PMID 1653651.
Guiton M, Gunn-Moore FJ, Glass DJ, et al. (1995). "Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling.". J. Biol. Chem. 270 (35): 20384-90. PMID 7657612.
McGregor LM, Baylin SB, Griffin CA, et al. (1995). "Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.". Genomics 22 (2): 267-72. doi:10.1006/geno.1994.1383. PMID 7806211.
Shelton DL, Sutherland J, Gripp J, et al. (1995). "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.". J. Neurosci. 15 (1 Pt 2): 477-91. PMID 7823156.
Pflug BR, Dionne C, Kaplan DR, et al. (1995). "Expression of a Trk high affinity nerve growth factor receptor in the human prostate.". Endocrinology 136 (1): 262-8. PMID 7828539.
Lamballe F, Tapley P, Barbacid M (1993). "trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities.". EMBO J. 12 (8): 3083-94. PMID 8344249.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yamamoto M, Sobue G, Yamamoto K, et al. (1997). "Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues.". Neurochem. Res. 21 (8): 929-38. PMID 8895847.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Valent A, Danglot G, Bernheim A (1997). "Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization.". Eur. J. Hum. Genet. 5 (2): 102-4. PMID 9195161.
Terenghi G, Mann D, Kopelman PG, Anand P (1997). "trkA and trkC expression is increased in human diabetic skin.". Neurosci. Lett. 228 (1): 33-6. PMID 9197281.
Knezevich SR, McFadden DE, Tao W, et al. (1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.". Nat. Genet. 18 (2): 184-7. doi:10.1038/ng0298-184. PMID 9462753.
Urfer R, Tsoulfas P, O'Connell L, et al. (1998). "High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors.". J. Biol. Chem. 273 (10): 5829-40. PMID 9488719.
Hu YQ, Koo PH (1998). "Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin.". J. Neurochem. 71 (1): 213-20. PMID 9648868.
Ichaso N, Rodriguez RE, Martin-Zanca D, Gonzalez-Sarmiento R (1998). "Genomic characterization of the human trkC gene.". Oncogene 17 (14): 1871-5. doi:10.1038/sj.onc.1202100. PMID 9778053.
Qian X, Riccio A, Zhang Y, Ginty DD (1999). "Identification and characterization of novel substrates of Trk receptors in developing neurons.". Neuron 21 (5): 1017-29. PMID 9856458.
Bibel M, Hoppe E, Barde YA (1999). "Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR.". EMBO J. 18 (3): 616-22. doi:10.1093/emboj/18.3.616. PMID 9927421.
Labouyrie E, Dubus P, Groppi A, et al. (1999). "Expression of neurotrophins and their receptors in human bone marrow.". Am. J. Pathol. 154 (2): 405-15. PMID 10027399.