NTHL1

From Wikipedia, the free encyclopedia

Nth endonuclease III-like 1 (E. coli)

Identifiers

NTHL1; NTH1; OCTS3

External IDs

OMIM: 602656 MGI: 1313275 HomoloGene: 1897

Gene ontology
Molecular Function:	• DNA binding • DNA-(apurinic or apyrimidinic site) lyase activity • endonuclease activity • iron ion binding • hydrolase activity, acting on glycosyl bonds • lyase activity • DNA N-glycosylase activity • metal ion binding • 4 iron, 4 sulfur cluster binding
Cellular Component:	• intracellular • nucleus • mitochondrion
Biological Process:	• base-excision repair • nucleotide-excision repair, DNA incision, 5'-to lesion • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002528 (mRNA)
NP_002519 (protein)

NM_008743 (mRNA)
NP_032769 (protein)

Location

Chr 16: 2.03 - 2.04 Mb

Chr 17: 24.36 - 24.37 Mb

Pubmed search

[1]

[2]

Nth endonuclease III-like 1 (E. coli), also known as NTHL1, is a human gene.^[1]

[edit] References

^ Entrez Gene: NTHL1 nth endonuclease III-like 1 (E. coli).

[edit] Further reading

Hilbert TP, Boorstein RJ, Kung HC, et al. (1996). "Purification of a mammalian homologue of Escherichia coli endonuclease III: identification of a bovine pyrimidine hydrate-thymine glycol DNAse/AP lyase by irreversible cross linking to a thymine glycol-containing oligoxynucleotide.". Biochemistry 35 (8): 2505–11. doi:10.1021/bi952516e. PMID 8611553.
Aspinwall R, Rothwell DG, Roldan-Arjona T, et al. (1997). "Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III.". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 109–14. PMID 8990169.
Hilbert TP, Chaung W, Boorstein RJ, et al. (1997). "Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III.". J. Biol. Chem. 272 (10): 6733–40. PMID 9045706.
Ikeda S, Biswas T, Roy R, et al. (1998). "Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue.". J. Biol. Chem. 273 (34): 21585–93. PMID 9705289.
Sarker AH, Ikeda S, Nakano H, et al. (1999). "Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III.". J. Mol. Biol. 282 (4): 761–74. doi:10.1006/jmbi.1998.2042. PMID 9743625.
Imai K, Sarker AH, Akiyama K, et al. (1999). "Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.". Gene 222 (2): 287–95. PMID 9831664.
Bessho T (1999). "Nucleotide excision repair 3' endonuclease XPG stimulates the activity of base excision repairenzyme thymine glycol DNA glycosylase.". Nucleic Acids Res. 27 (4): 979–83. PMID 9927729.
Luna L, Bjørås M, Hoff E, et al. (2000). "Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA.". Mutat. Res. 460 (2): 95–104. PMID 10882850.
Matsumoto Y, Zhang QM, Takao M, et al. (2002). "Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA.". Nucleic Acids Res. 29 (9): 1975–81. PMID 11328882.
Miyabe I, Zhang QM, Kino K, et al. (2002). "Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein.". Nucleic Acids Res. 30 (15): 3443–8. PMID 12140329.
Liu X, Roy R (2002). "Truncation of amino-terminal tail stimulates activity of human endonuclease III (hNTH1).". J. Mol. Biol. 321 (2): 265–76. PMID 12144783.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Marenstein DR, Chan MK, Altamirano A, et al. (2003). "Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity.". J. Biol. Chem. 278 (11): 9005–12. doi:10.1074/jbc.M212168200. PMID 12519758.
Ikeda S, Kohmoto T, Tabata R, Seki Y (2003). "Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals.". DNA Repair (Amst.) 1 (10): 847–54. PMID 12531031.
Liu X, Choudhury S, Roy R (2004). "In vitro and in vivo dimerization of human endonuclease III stimulates its activity.". J. Biol. Chem. 278 (50): 50061–9. doi:10.1074/jbc.M309997200. PMID 14522981.
Katafuchi A, Nakano T, Masaoka A, et al. (2004). "Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions.". J. Biol. Chem. 279 (14): 14464–71. doi:10.1074/jbc.M400393200. PMID 14734554.
Wiederhold L, Leppard JB, Kedar P, et al. (2004). "AP endonuclease-independent DNA base excision repair in human cells.". Mol. Cell 15 (2): 209–20. doi:10.1016/j.molcel.2004.06.003. PMID 15260972.
Oyama M, Wakasugi M, Hama T, et al. (2004). "Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen.". Biochem. Biophys. Res. Commun. 321 (1): 183–91. doi:10.1016/j.bbrc.2004.06.136. PMID 15358233.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang QM, Yonekura S, Takao M, et al. (2005). "DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.". DNA Repair (Amst.) 4 (1): 71–9. doi:10.1016/j.dnarep.2004.08.002. PMID 15533839.