NT5C

From Wikipedia, the free encyclopedia

5', 3'-nucleotidase, cytosolic

Identifiers

NT5C; DNT; DNT1; P5N2; PN-I; PN-II; UMPH2; cdN; dNT-1

External IDs

OMIM: 191720 MGI: 1354954 HomoloGene: 8745

Gene ontology
Molecular Function:	• magnesium ion binding • 5'-nucleotidase activity • hydrolase activity • pyrimidine nucleotide binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• nucleotide metabolic process • pyrimidine deoxyribonucleotide catabolic process • dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014595 (mRNA)
NP_055410 (protein)

NM_015807 (mRNA)
NP_056622 (protein)

Location

Chr 17: 70.64 - 70.64 Mb

Chr 11: 115.31 - 115.31 Mb

Pubmed search

[1]

[2]

5', 3'-nucleotidase, cytosolic, also known as NT5C, is a human gene.^[1]

Pyrimidine 5-prime nucleotidase (P5N; EC 3.1.3.5), also called uridine 5-prime monophosphate hydrolase (UMPH), catalyzes the dephosphorylation of the pyrimidine 5-prime monophosphates UMP and CMP to the corresponding nucleosides. There are 2 isozymes of pyrimidine 5-prime nucleotidase in red blood cells, referred to as type I (UMPH1; MIM 606224) and type II (UMPH2).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NT5C 5', 3'-nucleotidase, cytosolic.

[edit] Further reading

Höglund L, Reichard P (1990). "Cytoplasmic 5'(3')-nucleotidase from human placenta.". J. Biol. Chem. 265 (12): 6589–95. PMID 2157703.
Wilson DE, Swallow DM, Povey S (1988). "Assignment of the human gene for uridine 5'-monophosphate phosphohydrolase (UMPH2) to the long arm of chromosome 17.". Ann. Hum. Genet. 50 (Pt 3): 223–7. PMID 2833155.
Xu WM, Gorman PA, Rider SH, et al. (1988). "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer.". Proc. Natl. Acad. Sci. U.S.A. 85 (22): 8563–7. PMID 3186746.
Rampazzo C, Johansson M, Gallinaro L, et al. (2000). "Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells.". J. Biol. Chem. 275 (8): 5409–15. PMID 10681516.
Rampazzo C, Gallinaro L, Milanesi E, et al. (2000). "A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8239–44. PMID 10899995.
Rampazzo C, Kost-Alimova M, Ruzzenente B, et al. (2003). "Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs.". Gene 294 (1-2): 109–17. PMID 12234672.
Amici A, Emanuelli M, Ruggieri S, et al. (2003). "Kinetic evidence for covalent phosphoryl-enzyme intermediate in phosphotransferase activity of human red cell pyrimidine nucleotidases.". Meth. Enzymol. 354: 149–59. PMID 12418222.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Balta G, Gumruk F, Akarsu N, et al. (2003). "Molecular characterization of Turkish patients with pyrimidine 5' nucleotidase-I deficiency.". Blood 102 (5): 1900–3. doi:10.1182/blood-2003-02-0628. PMID 12714505.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Galmarini CM, Cros E, Graham K, et al. (2006). "5'-(3')-nucleotidase mRNA levels in blast cells are a prognostic factor in acute myeloid leukemia patients treated with cytarabine.". Haematologica 89 (5): 617–9. PMID 15136231.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.