NSP5 (rotavirus)

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NSP5 (nonstructural protein 5) encoded by genome segment 11 of group A rotaviruses. In virus-infected cells NSP5 accumulates in the viroplasms. NSP5 has been shown to be autophosphorylated.[1] Interaction of NSP5 with NSP2 was also demonstrated[2]. In rotavirus-infected cells, the non-structural proteins NSP5 and NSP2 localize in complexes called viroplasms, where replication and assembly occur and they can drive the formation of viroplasm-like structures in the absence of other rotaviral proteins and rotavirus replication.[3]

  1. ^ Afrikanova, I; M C Miozzo, S Giambiagi, O Burrone (1996- Sep). "Phosphorylation generates different forms of rotavirus NSP5.". The Journal of general virology 77 ( Pt 9): 2059–65. 8811003. 
  2. ^ Afrikanova, I; E Fabbretti, M C Miozzo, O R Burrone (1998- Nov). "Rotavirus NSP5 phosphorylation is up-regulated by interaction with NSP2.". The Journal of general virology 79 ( Pt 11): 2679–86. 9820143. 
  3. ^ Fabbretti, E; I Afrikanova, F Vascotto, O R Burrone (1999- Feb). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo.". The Journal of general virology 80 ( Pt 2): 333–9. 10073692. 
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