NSP4 (rotavirus)

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The rotavirus nonstructural protein NSP4 was the first viral enterotoxin discovered. It induces diarrhea and causes Ca2+-dependent transepithelial secretion.[1]

  1. ^ Dong, Y; C Q Zeng, J M Ball, M K Estes, A P Morris (1997- Apr- 15). "The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production.". Proceedings of the National Academy of Sciences of the United States of America 94 (8): 3960–5. doi:10.1073/pnas.94.8.3960. 9108087. 


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